Effects of RAGE inhibition on the progression of the disease in hSOD1

Amyotrophic Lateral Sclerosis / genetics Animals Astrocytes / metabolism Disease Models, Animal Disease Progression Female Male Mice Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Motor Neurons / pathology Receptor for Advanced Glycation End Products / genetics Superoxide Dismutase-1 / genetics
Atrogin-1 MuRF1 advanced glycation end products receptor amyotrophic lateral sclerosis astrocytes motor neurons

Journal

Pharmacology research & perspectives
ISSN: 2052-1707
Titre abrégé: Pharmacol Res Perspect
Pays: United States
ID NLM: 101626369

Informations de publication

Date de publication:
08 2020
Historique:
received: 09 07 2020
accepted: 13 07 2020
entrez: 11 8 2020
pubmed: 11 8 2020
medline: 4 6 2021
Statut: ppublish

Résumé

Astrocytes play a key role in the progression of amyotrophic lateral sclerosis (ALS) by actively inducing the degeneration of motor neurons. Motor neurons isolated from receptor for advanced glycation end products (RAGE)-knockout mice are resistant to the neurotoxic signal derived from ALS-astrocytes. Here, we confirmed that in a co-culture model, the neuronal death induced by astrocytes over-expressing the ALS-linked mutant hSOD1

Identifiants

DOI: 10.1002/prp2.636 PMID: 32776498 PMC: PMC7415959
pubmed: 32776498
doi: 10.1002/prp2.636
pmc: PMC7415959
doi:

Substances chimiques

Ager protein, mouse 0
Receptor for Advanced Glycation End Products 0
SOD1 protein, human 0
Superoxide Dismutase-1 EC 1.15.1.1

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e00636

Subventions

Organisme : NINDS NIH HHS
ID : R01NS100835
Pays : United States
Organisme : NIH HHS
ID : S10 OD018113
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS100835
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA138313
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM103542
Pays : United States

Informations de copyright

© 2020 The Authors. Pharmacology Research & Perspectives published by John Wiley & Sons Ltd, British Pharmacological Society and American Society for Pharmacology and Experimental Therapeutics.

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Auteurs

Liping Liu (L)

Biomedical Sciences Training Program, Department of Pharmacology and Experimental Therapeutics, Medical University of South Carolina, Charleston, SC, USA.

Kelby M Killoy (KM)

Biomedical Sciences Training Program, Department of Pharmacology and Experimental Therapeutics, Medical University of South Carolina, Charleston, SC, USA.

Marcelo R Vargas (MR)

Department of Neurology, University of Wisconsin-Madison, Madison, WI, USA.
ORCID: 0000-0003-1039-4210

Yasuhiko Yamamoto (Y)

Department of Biochemistry and Molecular Vascular Biology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan.

Mariana Pehar (M)

Division of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA.
Geriatric Research Education Clinical Center, Veterans Affairs Medical Center, Madison, WI, USA.
ORCID: 0000-0002-1231-4563

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Classifications MeSH

questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Troubles de l'homéostasie des protéines › Protéinopathies TDP-43 › Sclérose latérale amyotrophique › Effects of RAGE inhibition on the progression...
questionsmedicales.fr › Eucaryotes › Animaux › Effects of RAGE inhibition on the progression...
questionsmedicales.fr › Cellules › Névroglie › Astrocytes › Effects of RAGE inhibition on the progression...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Effects of RAGE inhibition on the progression...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Évolution de la maladie › Effects of RAGE inhibition on the progression...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Effects of RAGE inhibition on the progression...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Effects of RAGE inhibition on the progression...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Effects of RAGE inhibition on the progression...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Effects of RAGE inhibition on the progression...
questionsmedicales.fr › Cellules › Neurones › Neurones efférents › Motoneurones › Effects of RAGE inhibition on the progression...
questionsmedicales.fr › Facteurs biologiques › Médiateurs de l'inflammation › Récepteur spécifique des produits finaux de glycosylation avancée › Effects of RAGE inhibition on the progression...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Superoxide dismutase › Superoxide dismutase-1 › Effects of RAGE inhibition on the progression...