Testosterone supplementation upregulates androgen receptor expression and translational capacity during severe energy deficit.
Adolescent
Adult
Body Composition
Diet
Energy Metabolism
/ drug effects
Exercise
Hormones
/ blood
Humans
Male
Muscle, Skeletal
/ drug effects
Protein Modification, Translational
/ drug effects
Receptors, Androgen
/ biosynthesis
Receptors, Interleukin-6
/ metabolism
TWEAK Receptor
/ metabolism
Testosterone
/ pharmacology
Up-Regulation
Young Adult
androgen receptor
inflammation
muscle mass
myonuclear accretion
negative energy balance
translational capacity
Journal
American journal of physiology. Endocrinology and metabolism
ISSN: 1522-1555
Titre abrégé: Am J Physiol Endocrinol Metab
Pays: United States
ID NLM: 100901226
Informations de publication
Date de publication:
01 10 2020
01 10 2020
Historique:
pubmed:
11
8
2020
medline:
1
1
2021
entrez:
11
8
2020
Statut:
ppublish
Résumé
Testosterone supplementation during energy deficit promotes whole body lean mass accretion, but the mechanisms underlying that effect remain unclear. To elucidate those mechanisms, skeletal muscle molecular adaptations were assessed from muscle biopsies collected before, 1 h, and 6 h after exercise and a mixed meal (40 g protein, 1 h postexercise) following 14 days of weight maintenance (WM) and 28 days of an exercise- and diet-induced 55% energy deficit (ED) in 50 physically active nonobese men treated with 200 mg testosterone enanthate/wk (TEST) or placebo (PLA) during the ED. Participants (
Identifiants
pubmed: 32776828
doi: 10.1152/ajpendo.00157.2020
pmc: PMC7750513
doi:
Substances chimiques
Hormones
0
IL6R protein, human
0
Receptors, Androgen
0
Receptors, Interleukin-6
0
TNFRSF12A protein, human
0
TWEAK Receptor
0
Testosterone
3XMK78S47O
Types de publication
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
E678-E688Subventions
Organisme : NIA NIH HHS
ID : R21 AG055415
Pays : United States
Organisme : NIGMS NIH HHS
ID : U54 GM104940
Pays : United States
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