Development of Disordered Eating Behaviors and Comorbid Depressive Symptoms in Adolescence: Neural and Psychopathological Predictors.

Adolescent Attention Deficit Disorder with Hyperactivity / epidemiology Comorbidity Depression / epidemiology Dorsolateral Prefrontal Cortex Feeding and Eating Disorders / epidemiology Gray Matter Humans
Attention-deficit/hyperactivity disorder Biomarkers Conduct disorder Depression Eating disorders Gray matter volume

Journal

Biological psychiatry
ISSN: 1873-2402
Titre abrégé: Biol Psychiatry
Pays: United States
ID NLM: 0213264

Informations de publication

Date de publication:
15 12 2021
Historique:
received: 13 11 2019
revised: 01 06 2020
accepted: 01 06 2020
pubmed: 12 8 2020
medline: 5 1 2022
entrez: 12 8 2020
Statut: ppublish

Résumé

Eating disorders are common in adolescence and are devastating and strongly comorbid with other psychiatric disorders. Yet little is known about their etiology, knowing which would aid in developing effective preventive measures. Longitudinal assessments of disordered eating behaviors (DEBs)-binge-eating, purging, and dieting-and comorbid psychopathology were measured in 1386 adolescents from the IMAGEN study. Development of DEBs and associated mental health problems was investigated by comparing participants who reported symptoms at ages 16 or 19 years, but not at age 14 years, with asymptomatic control participants. Voxel-based morphometry and psychopathological differences at age 14 were investigated to identify risk factors for the development of DEBs and associated mental health problems. DEBs and depressive symptoms developed together. Emotional and behavioral problems, including symptoms of attention-deficit/hyperactivity disorder and conduct disorder, predated their development. Alterations in frontostriatal brain areas also predated the development of DEBs and depressive symptoms. Specifically, development of binge-eating was predicted by higher gray matter volumes in the right putamen/globus pallidus at age 14. Conversely, development of purging and depressive symptoms was predicted by lower volumes in the medial orbitofrontal, dorsomedial, and dorsolateral prefrontal cortices. Lower gray matter volumes in the orbitofrontal and anterior cingulate cortices mediated the relationship between attention-deficit/hyperactivity disorder and conduct disorder symptoms and future purging and depressive symptoms. These findings suggest that alterations in frontal brain circuits are part of the shared etiology among eating disorders, attention-deficit/hyperactivity disorder, conduct disorder, and depression and highlight the importance of a transdiagnostic approach to treating these conditions.

Sections du résumé

BACKGROUND
Eating disorders are common in adolescence and are devastating and strongly comorbid with other psychiatric disorders. Yet little is known about their etiology, knowing which would aid in developing effective preventive measures.
METHODS
Longitudinal assessments of disordered eating behaviors (DEBs)-binge-eating, purging, and dieting-and comorbid psychopathology were measured in 1386 adolescents from the IMAGEN study. Development of DEBs and associated mental health problems was investigated by comparing participants who reported symptoms at ages 16 or 19 years, but not at age 14 years, with asymptomatic control participants. Voxel-based morphometry and psychopathological differences at age 14 were investigated to identify risk factors for the development of DEBs and associated mental health problems.
RESULTS
DEBs and depressive symptoms developed together. Emotional and behavioral problems, including symptoms of attention-deficit/hyperactivity disorder and conduct disorder, predated their development. Alterations in frontostriatal brain areas also predated the development of DEBs and depressive symptoms. Specifically, development of binge-eating was predicted by higher gray matter volumes in the right putamen/globus pallidus at age 14. Conversely, development of purging and depressive symptoms was predicted by lower volumes in the medial orbitofrontal, dorsomedial, and dorsolateral prefrontal cortices. Lower gray matter volumes in the orbitofrontal and anterior cingulate cortices mediated the relationship between attention-deficit/hyperactivity disorder and conduct disorder symptoms and future purging and depressive symptoms.
CONCLUSIONS
These findings suggest that alterations in frontal brain circuits are part of the shared etiology among eating disorders, attention-deficit/hyperactivity disorder, conduct disorder, and depression and highlight the importance of a transdiagnostic approach to treating these conditions.

Identifiants

DOI: 10.1016/j.biopsych.2020.06.003 PMID: 32778392
pubmed: 32778392
pii: S0006-3223(20)31672-3
doi: 10.1016/j.biopsych.2020.06.003
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

853-862

Subventions

Organisme : Medical Research Council
ID : MR/R00465X/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S020306/1
Pays : United Kingdom
Organisme : MRF
ID : MRF_MRF-058-0004-RG-DESRI
Pays : United Kingdom
Organisme : MRF
ID : MRF_MRF-058-0009-RG-DESR-C0759
Pays : United Kingdom

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2020 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.

Auteurs

Zuo Zhang (Z)

Centre for Population Neuroscience and Precision Medicine, Institute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry Centre, King's College London, London, United Kingdom.

Lauren Robinson (L)

Section of Eating Disorders, Department of Psychological Medicine, London, United Kingdom.

Tianye Jia (T)

Centre for Population Neuroscience and Precision Medicine, Institute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry Centre, King's College London, London, United Kingdom; Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China; Ministry of Education-Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence, Fudan University, Shanghai, China.

Erin Burke Quinlan (EB)

Centre for Population Neuroscience and Precision Medicine, Institute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry Centre, King's College London, London, United Kingdom.

Nicole Tay (N)

Centre for Population Neuroscience and Precision Medicine, Institute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry Centre, King's College London, London, United Kingdom.

Congying Chu (C)

Centre for Population Neuroscience and Precision Medicine, Institute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry Centre, King's College London, London, United Kingdom.

Edward D Barker (ED)

Centre for Population Neuroscience and Precision Medicine, Institute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry Centre, King's College London, London, United Kingdom; Developmental Psychopathology Lab, Department of Psychology, King's College London, London, United Kingdom.

Tobias Banaschewski (T)

Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

Gareth J Barker (GJ)

Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.

Arun L W Bokde (ALW)

Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College, Dublin, Ireland.

Herta Flor (H)

Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; Department of Psychology, School of Social Sciences, University of Mannheim, Mannheim, Germany.

Antoine Grigis (A)

NeuroSpin, Commissariat à l'Énergie Atomique, Université Paris-Saclay, Gif-sur-Yvette, France.

Hugh Garavan (H)

Departments of Psychiatry and Psychology, University of Vermont, Burlington, Vermont, USA.

Penny Gowland (P)

Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, United Kingdom.

Andreas Heinz (A)

Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Campus Charite Mitte, Berlin, Germany.

Bernd Ittermann (B)

Physikalisch-Technische Bundesanstalt, Braunschweig and Berlin, Germany.

Jean-Luc Martinot (JL)

Institut National de la Santé et de la Recherche Médicale U A10 "Developmental Trajectories and Psychiatry", Université Paris-Saclay, École Normale Supérieure Paris-Saclay, Centre National de la Recherche Scientifique, Centre Borelli, Gif-sur-Yvette, France.

Argyris Stringaris (A)

National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA.

Jani Penttilä (J)

Department of Social and Health Care, Psychosocial Services Adolescent Outpatient Clinic, Kauppakatu, Lahti, Finland.

Betteke van Noort (B)

Medical School Berlin, Berlin, Germany.

Yvonne Grimmer (Y)

Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

Marie-Laure Paillère Martinot (ML)

Institut National de la Santé et de la Recherche Médicale Unit 1000 "Neuroimaging & Psychiatry", Université Paris-Saclay, Université Paris Descartes, Sorbonne Université, Paris, France; Department of Child and Adolescent Psychiatry, Assistance Publique-Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Paris, France.

Corinna Isensee (C)

Department of Child and Adolescent Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany.

Andreas Becker (A)

Department of Child and Adolescent Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany.

Frauke Nees (F)

Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; Institute of Medical Psychology and Medical Sociology, University Medical Center Schleswig Holstein, Kiel University, Kiel, Germany.

Dimitri Papadopoulos Orfanos (DP)

NeuroSpin, Commissariat à l'Énergie Atomique, Université Paris-Saclay, Gif-sur-Yvette, France.

Tomáš Paus (T)

Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, Toronto, Ontario, Canada; Departments of Psychology and Psychiatry, University of Toronto, Toronto, Ontario, Canada.

Luise Poustka (L)

Department of Child and Adolescent Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany.

Sarah Hohmann (S)

Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

Juliane H Fröhner (JH)

Department of Psychiatry and Neuroimaging Center, Technische Universitat Dresden, Dresden, Germany.

Michael N Smolka (MN)

Department of Psychiatry and Neuroimaging Center, Technische Universitat Dresden, Dresden, Germany.

Henrik Walter (H)

Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Campus Charite Mitte, Berlin, Germany.

Robert Whelan (R)

School of Psychology and Global Brain Health Institute, Trinity College, Dublin, Ireland.

Gunter Schumann (G)

Centre for Population Neuroscience and Precision Medicine, Institute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry Centre, King's College London, London, United Kingdom; Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China; Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Campus Charite Mitte, Berlin, Germany.

Ulrike Schmidt (U)

Section of Eating Disorders, Department of Psychological Medicine, London, United Kingdom; The Eating Disorders Service, Maudsley Hospital, South London, and Maudsley NHS Foundation Trust, London, United Kingdom.

Sylvane Desrivières (S)

Centre for Population Neuroscience and Precision Medicine, Institute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry Centre, King's College London, London, United Kingdom. Electronic address: sylvane.desrivieres@kcl.ac.uk.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adolescent › Development of Disordered Eating Behaviors and...
questionsmedicales.fr › Troubles mentaux › Troubles du développement neurologique › Troubles déficitaires de l'attention et du comportement perturbateur › Trouble déficitaire de l'attention avec hyperactivité › Development of Disordered Eating Behaviors and...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Facteurs épidémiologiques › Comorbidité › Development of Disordered Eating Behaviors and...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Émotions › Dépression › Development of Disordered Eating Behaviors and...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Lobe frontal › Cortex préfrontal › Cortex préfrontal dorsolatéral › Development of Disordered Eating Behaviors and...
questionsmedicales.fr › Troubles mentaux › Troubles de l'alimentation › Development of Disordered Eating Behaviors and...
questionsmedicales.fr › Système nerveux › Système nerveux central › Moelle spinale › Substance grise › Development of Disordered Eating Behaviors and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Development of Disordered Eating Behaviors and...