Orbitofrontal-striatal potentiation underlies cocaine-induced hyperactivity.
Animals
Behavior, Animal
Central Nervous System Stimulants
/ pharmacology
Cocaine
/ pharmacology
Corpus Striatum
/ drug effects
Disease Models, Animal
Dopamine
Female
Hyperkinesis
/ chemically induced
Locomotion
/ drug effects
Male
Mice
Mice, Inbred C57BL
Neurons
/ drug effects
Optogenetics
Prefrontal Cortex
/ drug effects
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
10 08 2020
10 08 2020
Historique:
received:
16
04
2020
accepted:
16
07
2020
entrez:
12
8
2020
pubmed:
12
8
2020
medline:
12
9
2020
Statut:
epublish
Résumé
Psychomotor stimulants increase dopamine levels in the striatum and promote locomotion; however, their effects on striatal pathway function in vivo remain unclear. One model that has been proposed to account for these motor effects suggests that stimulants drive hyperactivity via activation and inhibition of direct and indirect pathway striatal neurons, respectively. Although this hypothesis is consistent with the cellular actions of dopamine receptors and received support from optogenetic and chemogenetic studies, it has been rarely tested with in vivo recordings. Here, we test this model and observe that cocaine increases the activity of both pathways in the striatum of awake mice. These changes are linked to a dopamine-dependent cocaine-induced strengthening of upstream orbitofrontal cortex (OFC) inputs to the dorsomedial striatum (DMS) in vivo. Finally, depressing OFC-DMS pathway with a high frequency stimulation protocol in awake mice over-powers the cocaine-induced potentiation of OFC-DMS pathway and attenuates the expression of locomotor sensitization, directly linking OFC-DMS potentiation to cocaine-induced hyperactivity.
Identifiants
pubmed: 32778725
doi: 10.1038/s41467-020-17763-8
pii: 10.1038/s41467-020-17763-8
pmc: PMC7417999
doi:
Substances chimiques
Central Nervous System Stimulants
0
Cocaine
I5Y540LHVR
Dopamine
VTD58H1Z2X
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3996Subventions
Organisme : NIDA NIH HHS
ID : R21 DA047127
Pays : United States
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