Selective antibiofilm properties and biocompatibility of nano-ZnO and nano-ZnO/Ag coated surfaces.
Anti-Bacterial Agents
Anti-Infective Agents
Bacteria
/ drug effects
Biofilms
/ drug effects
Candida albicans
/ growth & development
Escherichia coli
/ growth & development
Metal Nanoparticles
/ therapeutic use
Microbial Sensitivity Tests
Nanocomposites
/ therapeutic use
Silver
/ metabolism
Staphylococcus aureus
/ growth & development
Zinc Oxide
/ metabolism
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
10 08 2020
10 08 2020
Historique:
received:
20
03
2020
accepted:
06
07
2020
entrez:
12
8
2020
pubmed:
12
8
2020
medline:
18
12
2020
Statut:
epublish
Résumé
Spread of pathogenic microbes and antibiotic-resistant bacteria in health-care settings and public spaces is a serious public health challenge. Materials that prevent solid surface colonization or impede touch-transfer of viable microbes could provide means to decrease pathogen transfer from high-touch surfaces in critical applications. ZnO and Ag nanoparticles have shown great potential in antimicrobial applications. Less is known about nano-enabled surfaces. Here we demonstrate that surfaces coated with nano-ZnO or nano-ZnO/Ag composites are not cytotoxic to human keratinocytes and possess species-selective medium-dependent antibiofilm activity against Escherichia coli, Staphylococcus aureus and Candida albicans. Colonization of nano-ZnO and nano-ZnO/Ag surfaces by E. coli and S. aureus was decreased in static oligotrophic conditions (no planktonic growth). Moderate to no effect was observed for bacterial biofilms in growth medium (supporting exponential growth). Inversely, nano-ZnO surfaces enhanced biofilm formation by C. albicans in oligotrophic conditions. However, enhanced C. albicans biofilm formation on nano-ZnO surfaces was effectively counteracted by the addition of Ag. Possible selective enhancement of biofilm formation by the yeast C. albicans on Zn-enabled surfaces should be taken into account in antimicrobial surface development. Our results also indicated the importance of the use of application-appropriate test conditions and exposure medium in antimicrobial surface testing.
Identifiants
pubmed: 32778787
doi: 10.1038/s41598-020-70169-w
pii: 10.1038/s41598-020-70169-w
pmc: PMC7417576
doi:
Substances chimiques
Anti-Bacterial Agents
0
Anti-Infective Agents
0
Silver
3M4G523W1G
Zinc Oxide
SOI2LOH54Z
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
13478Références
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