Test-retest reliability of the Friedreich's ataxia rating scale.


Journal

Annals of clinical and translational neurology
ISSN: 2328-9503
Titre abrégé: Ann Clin Transl Neurol
Pays: United States
ID NLM: 101623278

Informations de publication

Date de publication:
09 2020
Historique:
received: 17 05 2020
accepted: 08 06 2020
pubmed: 12 8 2020
medline: 21 10 2021
entrez: 12 8 2020
Statut: ppublish

Résumé

The modified Friedreich Ataxia Rating Scale (mFARS) is a disease specific, exam-based neurological rating scale commonly used as a outcome measure in clinical trials. While extensive clinimetric testing indicates it's validity in measuring disease progression, formal test-retest reliability was lacking. To fill this gap, we acquired results from screening and baseline visits of several large clinical trials and calculated intraclass correlation coefficients, coefficients of variance, standard error, and the minimally detectable changes. This study demonstrated excellent test-retest reliability of the mFARS, and it's upright stability subscore.

Identifiants

pubmed: 32779859
doi: 10.1002/acn3.51118
pmc: PMC7480910
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1708-1712

Informations de copyright

© 2020 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.

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Auteurs

Christian Rummey (C)

Clinical Data Science GmbH, Basel, Switzerland.

Theresa A Zesiewicz (TA)

University of South Florida Ataxia Research Center, Tampa, Florida.

Santiago Perez-Lloret (S)

Institute of Cardiological Research, University of Buenos Aires, National Research Council (ININCA-UBA-CONICET), Marcelo T. de Alvear 2270, Buenos Aires, C1122, Argentina.
Department of Physiology, School of Medicine, University of Buenos Aires (UBA), Buenos Aires, Argentina.

Jennifer M Farmer (JM)

Friedreich's Ataxia Research Alliance, Downingtown, Pennsylvania.

Massimo Pandolfo (M)

Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium.

David R Lynch (DR)

Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

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Classifications MeSH