The genetic architecture of human brainstem structures and their involvement in common brain disorders.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
11 08 2020
11 08 2020
Historique:
received:
08
12
2019
accepted:
23
06
2020
entrez:
13
8
2020
pubmed:
13
8
2020
medline:
12
9
2020
Statut:
epublish
Résumé
Brainstem regions support vital bodily functions, yet their genetic architectures and involvement in common brain disorders remain understudied. Here, using imaging-genetics data from a discovery sample of 27,034 individuals, we identify 45 brainstem-associated genetic loci, including the first linked to midbrain, pons, and medulla oblongata volumes, and map them to 305 genes. In a replication sample of 7432 participants most of the loci show the same effect direction and are significant at a nominal threshold. We detect genetic overlap between brainstem volumes and eight psychiatric and neurological disorders. In additional clinical data from 5062 individuals with common brain disorders and 11,257 healthy controls, we observe differential volume alterations in schizophrenia, bipolar disorder, multiple sclerosis, mild cognitive impairment, dementia, and Parkinson's disease, supporting the relevance of brainstem regions and their genetic architectures in common brain disorders.
Identifiants
pubmed: 32782260
doi: 10.1038/s41467-020-17376-1
pii: 10.1038/s41467-020-17376-1
pmc: PMC7421944
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4016Investigateurs
L Farde
(L)
L Flyckt
(L)
G Engberg
(G)
S Erhardt S
(S)
H Fatouros-Bergman
(H)
S Cervenka
(S)
L Schwieler
(L)
F Piehl
(F)
I Agartz
(I)
K Collste
(K)
P Victorsson
(P)
A Malmqvist
(A)
M Hedberg
(M)
F Orhan
(F)
C M Sellgren
(CM)
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