ACE2 (Angiotensin-Converting Enzyme 2) in Cardiopulmonary Diseases: Ramifications for the Control of SARS-CoV-2.

Angiotensin-Converting Enzyme 2 Betacoronavirus / physiology COVID-19 Coronavirus Infections / metabolism Disease Management Humans Hypertension, Pulmonary / metabolism Pandemics Peptidyl-Dipeptidase A / physiology Pneumonia, Viral / metabolism Renin-Angiotensin System / physiology SARS-CoV-2
COVID-19 angiotensin-converting enzyme 2 brain-gut-lung axis lung disease pulmonary hypertension renin-angiotensin system severe acute respiratory syndrome coronavirus-2

Journal

Hypertension (Dallas, Tex. : 1979)
ISSN: 1524-4563
Titre abrégé: Hypertension
Pays: United States
ID NLM: 7906255

Informations de publication

Date de publication:
09 2020
Historique:
entrez: 14 8 2020
pubmed: 14 8 2020
medline: 26 8 2020
Statut: ppublish

Résumé

Discovery of ACE2 (angiotensin-converting enzyme 2) revealed that the renin-angiotensin system has 2 counterbalancing arms. ACE2 is a major player in the protective arm, highly expressed in lungs and gut with the ability to mitigate cardiopulmonary diseases such as inflammatory lung disease. ACE2 also exhibits activities involving gut microbiome, nutrition, and as a chaperone stabilizing the neutral amino acid transporter, B

Identifiants

DOI: 10.1161/HYPERTENSIONAHA.120.15595 PMID: 32783758 PMC: PMC7430041
pubmed: 32783758
doi: 10.1161/HYPERTENSIONAHA.120.15595
pmc: PMC7430041
mid: NIHMS1609774
doi:

Substances chimiques

Peptidyl-Dipeptidase A EC 3.4.15.1
ACE2 protein, human EC 3.4.17.23
Angiotensin-Converting Enzyme 2 EC 3.4.17.23

Types de publication

Journal Article Research Support, N.I.H., Extramural Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

651-661

Subventions

Organisme : NHLBI NIH HHS
ID : R01 HL102033
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY028858
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY024564
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY021752
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL132448
Pays : United States

Commentaires et corrections

Type : CommentIn

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Auteurs

Ravindra K Sharma (RK)

From the Division of Nephrology, Hypertension and Renal Transplantation, Department of Medicine (R.K.S.), University of Florida College of Medicine, Gainesville.

Bruce R Stevens (BR)

Department of Physiology and Functional Genomics (B.R.S., E.M.R., M.K.R.), University of Florida College of Medicine, Gainesville.

Alexander G Obukhov (AG)

Department of Anatomy, Cell Biology & Physiology, Indiana University School of Medicine, Indianapolis (A.G.O.).

Maria B Grant (MB)

Department of Ophthalmology and Visual Sciences, University of Alabama College of Medicine, Birmingham (M.B.G.).

Gavin Y Oudit (GY)

Department of Medicine, University of Alberta College of Medicine, Edmonton, Canada (G.Y.O.).

Qiuhong Li (Q)

Department of Ophthalmology (Q.L.), University of Florida College of Medicine, Gainesville.

Elaine M Richards (EM)

Department of Physiology and Functional Genomics (B.R.S., E.M.R., M.K.R.), University of Florida College of Medicine, Gainesville.

Carl J Pepine (CJ)

Division of Cardiovascular Medicine, Department of Medicine (C.J.P.), University of Florida College of Medicine, Gainesville.

Mohan K Raizada (MK)

Department of Physiology and Functional Genomics (B.R.S., E.M.R., M.K.R.), University of Florida College of Medicine, Gainesville.

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Classifications MeSH

questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Peptide hydrolases › Exopeptidases › Carboxypeptidases › Angiotensin-converting enzyme 2 › ACE2 (Angiotensin-Converting Enzyme 2) in...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Nidovirales › Coronaviridae › Coronavirus › Betacoronavirus › ACE2 (Angiotensin-Converting Enzyme 2) in...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Pneumopathie virale › COVID-19 › ACE2 (Angiotensin-Converting Enzyme 2) in...
questionsmedicales.fr › Infection › Maladies virales › Infections à virus à ARN › Infections à Nidovirales › Infections à Coronaviridae › Infections à coronavirus › ACE2 (Angiotensin-Converting Enzyme 2) in...
questionsmedicales.fr › Administration des services de santé › Gestion des soins aux patients › Prise en charge de la maladie › ACE2 (Angiotensin-Converting Enzyme 2) in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › ACE2 (Angiotensin-Converting Enzyme 2) in...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Hypertension artérielle › Hypertension pulmonaire › ACE2 (Angiotensin-Converting Enzyme 2) in...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Épidémies de maladies › Épidémies › Pandémies › ACE2 (Angiotensin-Converting Enzyme 2) in...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Peptide hydrolases › Exopeptidases › Dipeptidyl-Peptidases and Tripeptidyl-Peptidases › Peptidyl-Dipeptidase A › ACE2 (Angiotensin-Converting Enzyme 2) in...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Pneumopathie virale › ACE2 (Angiotensin-Converting Enzyme 2) in...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Hémodynamique › Système rénine-angiotensine › ACE2 (Angiotensin-Converting Enzyme 2) in...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Nidovirales › Coronaviridae › Coronavirus › Betacoronavirus › Virus du SRAS › SARS-CoV-2 › ACE2 (Angiotensin-Converting Enzyme 2) in...