Role of miR-302/367 cluster in human physiology and pathophysiology.
Animals
Cardiovascular Diseases
/ genetics
Cell Proliferation
Cellular Reprogramming
Human Embryonic Stem Cells
/ metabolism
Humans
Immune System Diseases
/ genetics
Induced Pluripotent Stem Cells
/ metabolism
MicroRNAs
/ genetics
Multigene Family
Neoplasms
/ genetics
Nervous System Diseases
/ genetics
RNA, Neoplasm
/ genetics
cancer
cardiovascular system
central nervous system
miR-302/367 cluster
pluripotent stem cells
Journal
Acta biochimica et biophysica Sinica
ISSN: 1745-7270
Titre abrégé: Acta Biochim Biophys Sin (Shanghai)
Pays: China
ID NLM: 101206716
Informations de publication
Date de publication:
05 Aug 2020
05 Aug 2020
Historique:
received:
08
01
2020
revised:
22
05
2020
accepted:
26
12
2019
entrez:
14
8
2020
pubmed:
14
8
2020
medline:
7
1
2021
Statut:
ppublish
Résumé
MicroRNAs (miRNAs) are small non-coding RNAs that negatively regulate target mRNAs at the post-transcriptional level. Increasing evidence shows the involvement of miRNAs in diverse biological processes. miR-302/367 cluster is highly conserved among vertebrates and made up of five members, including miR-367, miR-302a, miR-302b, miR-302c and miR-302d. miR-302/367 cluster plays an important role in cell proliferation, differentiation and reprogramming, affecting the development of tumor, cardiovascular system, nervous system and immune system. In this review, we will summarize the role of miR-302/367 cluster in embryonic stem cells and induced pluripotent stem cells and try to point out its relationship with tumors, cardiovascular system, nervous system and immune system.
Identifiants
pubmed: 32785592
pii: 5866781
doi: 10.1093/abbs/gmaa065
doi:
Substances chimiques
MIRN302A microRNA, human
0
MIRN367 microRNA, human
0
MicroRNAs
0
RNA, Neoplasm
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
791-800Informations de copyright
© The Author(s) 2020. Published by Oxford University Press on behalf of the Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.