Head-to-Tail Cyclization after Interaction with Trypsin: A Scorpion Venom Peptide that Resembles Plant Cyclotides.

Amino Acid Sequence Animals CHO Cells Cricetulus Cyclization Cyclotides / chemistry Models, Molecular Protein Binding Protein Conformation Scorpion Venoms / chemistry Trypsin / metabolism

Journal

Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531

Informations de publication

Date de publication:
10 09 2020
Historique:
pubmed: 14 8 2020
medline: 15 12 2020
entrez: 14 8 2020
Statut: ppublish

Résumé

Peptidase inhibitors (PIs) have been broadly studied due to their wide therapeutic potential for human diseases. A potent trypsin inhibitor from

Identifiants

DOI: 10.1021/acs.jmedchem.0c00686 PMID: 32787139
pubmed: 32787139
doi: 10.1021/acs.jmedchem.0c00686
doi:

Substances chimiques

Cyclotides 0
Scorpion Venoms 0
Trypsin EC 3.4.21.4

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

9500-9511

Auteurs

Caroline B F Mourão (CBF)

Neuropharma Lab, Departamento de Ciências Fisiológicas, Instituto de Ciências Biológicas, Universidade de Brası́lia, Brasília-DF 70910-900, Brazil.
Instituto Federal de Brası́lia, Campus Ceilándia, Brası́lia-DF 72220-260, Brazil.

Guilherme D Brand (GD)

Laboratório de Sı́ntese e Análise de Biomoléculas, LSAB, Instituto de Quı́mica, Universidade de Brası́lia, Brası́lia-DF 70910-900, Brazil.
ORCID: 0000-0002-1615-0009

João Paulo C Fernandes (JPC)

Laboratório de Biofı́sica Molecular, Departamento de Biologia Celular, Instituto de Ciências Biológicas, Universidade de Brası́lia, Brası́lia-DF 70910-900, Brazil.

Maura V Prates (MV)

Laboratório de Espectrometria de Massa, EMBRAPA Recursos Genéticos e Biotecnologia, Brası́lia-DF 70770-917, Brazil.

Carlos Bloch (C)

Laboratório de Espectrometria de Massa, EMBRAPA Recursos Genéticos e Biotecnologia, Brası́lia-DF 70770-917, Brazil.

João Alexandre R G Barbosa (JARG)

Laboratório de Biofı́sica Molecular, Departamento de Biologia Celular, Instituto de Ciências Biológicas, Universidade de Brası́lia, Brası́lia-DF 70910-900, Brazil.

Sônia M Freitas (SM)

Laboratório de Biofı́sica Molecular, Departamento de Biologia Celular, Instituto de Ciências Biológicas, Universidade de Brası́lia, Brası́lia-DF 70910-900, Brazil.

Rita Restano-Cassulini (R)

Instituto de Biotecnologı́a, Universidad Nacional Autónoma de México, Cuernavaca, Morelos 62210, Mexico.

Lourival D Possani (LD)

Instituto de Biotecnologı́a, Universidad Nacional Autónoma de México, Cuernavaca, Morelos 62210, Mexico.

Elisabeth F Schwartz (EF)

Neuropharma Lab, Departamento de Ciências Fisiológicas, Instituto de Ciências Biológicas, Universidade de Brası́lia, Brasília-DF 70910-900, Brazil.
ORCID: 0000-0001-8239-4055

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Classifications MeSH

questionsmedicales.fr › Sciences de l'information › Sources d'information › Services d'information › Documentation › Données de séquences moléculaires › Séquence d'acides aminés › Head-to-Tail Cyclization after Interaction...
questionsmedicales.fr › Eucaryotes › Animaux › Head-to-Tail Cyclization after Interaction...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules CHO › Head-to-Tail Cyclization after Interaction...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Arvicolinae › Cricetinae › Cricetulus › Head-to-Tail Cyclization after Interaction...
questionsmedicales.fr › Métabolisme › Cyclisation › Head-to-Tail Cyclization after Interaction...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Peptides cycliques › Cyclotides › Head-to-Tail Cyclization after Interaction...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles moléculaires › Head-to-Tail Cyclization after Interaction...
questionsmedicales.fr › Métabolisme › Liaison aux protéines › Head-to-Tail Cyclization after Interaction...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Head-to-Tail Cyclization after Interaction...
questionsmedicales.fr › Facteurs biologiques › Toxines biologiques › Venins › Venins d'arthropode › Venins de scorpion › Head-to-Tail Cyclization after Interaction...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Peptide hydrolases › Protéases à sérine › Serine endopeptidases › Trypsine › Head-to-Tail Cyclization after Interaction...