Novel Biphasic Lipolysis Method To Predict

Biological Availability Chemistry, Pharmaceutical / methods Humans Intestinal Absorption / physiology Lipids / chemistry Lipolysis / physiology Pharmaceutical Preparations / chemistry Reproducibility of Results Solubility / drug effects Soybean Oil / chemistry
absorption biphasic dissolution in vitro digestion in vitro−in vivo relationship (IVIVR) lipid-based formulations lipolysis

Journal

Molecular pharmaceutics
ISSN: 1543-8392
Titre abrégé: Mol Pharm
Pays: United States
ID NLM: 101197791

Informations de publication

Date de publication:
08 09 2020
Historique:
pubmed: 14 8 2020
medline: 7 7 2021
entrez: 14 8 2020
Statut: ppublish

Résumé

The absence of an intestinal absorption sink is a significant weakness of standard

Identifiants

DOI: 10.1021/acs.molpharmaceut.0c00427 PMID: 32787274
pubmed: 32787274
doi: 10.1021/acs.molpharmaceut.0c00427
doi:

Substances chimiques

Lipids 0
Pharmaceutical Preparations 0
Soybean Oil 8001-22-7

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

3342-3352

Auteurs

Patrick J O'Dwyer (PJ)

Pion Inc. (UK) Ltd., Forest Row RH18 5DW, East Sussex, U.K.
Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Zografou 157 72, Greece.
School of Pharmacy, University College Cork, College Road, Cork T12 YN60, Ireland.
ORCID: 0000-0002-5350-8364

Karl J Box (KJ)

Pion Inc. (UK) Ltd., Forest Row RH18 5DW, East Sussex, U.K.

Niklas J Koehl (NJ)

School of Pharmacy, University College Cork, College Road, Cork T12 YN60, Ireland.
ORCID: 0000-0002-0565-9192

Harriet Bennett-Lenane (H)

School of Pharmacy, University College Cork, College Road, Cork T12 YN60, Ireland.

Christos Reppas (C)

Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Zografou 157 72, Greece.

Rene Holm (R)

Drug Product Development, Janssen Research and Development, Johnson & Johnson, Turnhoutseweg 30, Beerse 2340, Belgium.
Department of Science and Environment, Roskilde University, Roskilde 4000, Denmark.

Martin Kuentz (M)

School of Life Sciences, Institute of Pharma Technology, University of Applied Sciences Northwest Switzerland, Hofackerstrasse 30, Muttenz 4132, Switzerland.
ORCID: 0000-0003-2963-2645

Brendan T Griffin (BT)

School of Pharmacy, University College Cork, College Road, Cork T12 YN60, Ireland.
ORCID: 0000-0001-5433-8398

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Pharmacocinétique › Biodisponibilité › Novel Biphasic Lipolysis Method To Predict
questionsmedicales.fr › Disciplines des sciences naturelles › Chimie › Chimie pharmaceutique › Novel Biphasic Lipolysis Method To Predict
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Novel Biphasic Lipolysis Method To Predict
questionsmedicales.fr › Phénomènes physiologiques de l'appareil buccodentaire et de l'appareil digestif › Phénomènes physiologiques de l'appareil digestif › Absorption gastro-intestinale › Absorption intestinale › Novel Biphasic Lipolysis Method To Predict
questionsmedicales.fr › Lipides › Novel Biphasic Lipolysis Method To Predict
questionsmedicales.fr › Métabolisme › Métabolisme lipidique › Lipolyse › Novel Biphasic Lipolysis Method To Predict
questionsmedicales.fr › Préparations pharmaceutiques › Novel Biphasic Lipolysis Method To Predict
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Méthodologie en recherche épidémiologique › Reproductibilité des résultats › Novel Biphasic Lipolysis Method To Predict
questionsmedicales.fr › Phénomènes chimiques › Solubilité › Novel Biphasic Lipolysis Method To Predict
questionsmedicales.fr › Aliments et boissons › Aliments › Matières grasses alimentaires › Matières grasses alimentaires insaturées › Huile de soja › Novel Biphasic Lipolysis Method To Predict