Higher CSF sTREM2 and microglia activation are associated with slower rates of beta-amyloid accumulation.
TREM2
beta-amyloid accumulation
microglia
protective
tau
Journal
EMBO molecular medicine
ISSN: 1757-4684
Titre abrégé: EMBO Mol Med
Pays: England
ID NLM: 101487380
Informations de publication
Date de publication:
07 09 2020
07 09 2020
Historique:
received:
09
03
2020
revised:
03
07
2020
accepted:
10
07
2020
pubmed:
14
8
2020
medline:
19
8
2021
entrez:
14
8
2020
Statut:
ppublish
Résumé
Microglia activation is the brain's major immune response to amyloid plaques in Alzheimer's disease (AD). Both cerebrospinal fluid (CSF) levels of soluble TREM2 (sTREM2), a biomarker of microglia activation, and microglia PET are increased in AD; however, whether an increase in these biomarkers is associated with reduced amyloid-beta (Aβ) accumulation remains unclear. To address this question, we pursued a two-pronged translational approach. Firstly, in non-demented and demented individuals, we tested CSF sTREM2 at baseline to predict (i) amyloid PET changes over ∼2 years and (ii) tau PET cross-sectionally assessed in a subset of patients. We found higher CSF sTREM2 associated with attenuated amyloid PET increase and lower tau PET. Secondly, in the App
Identifiants
pubmed: 32790063
doi: 10.15252/emmm.202012308
pmc: PMC7507349
doi:
Substances chimiques
Amyloid beta-Peptides
0
Biomarkers
0
Membrane Glycoproteins
0
Receptors, Immunologic
0
TREM2 protein, human
0
Trem2 protein, mouse
0
tau Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
e12308Subventions
Organisme : NIA NIH HHS
ID : P30 AG066444
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG064877
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG053303
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG024904
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG058501
Pays : United States
Organisme : U.S. Department of Defense (DOD)
ID : W81XWH-12-2-0012
Pays : International
Organisme : NIA NIH HHS
ID : T32 AG000213
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG044546
Pays : United States
Organisme : Deutsche Forschungsgemeinschaft (DFG)
ID : EXC 1010 SyNergy
Pays : International
Organisme : NIA NIH HHS
ID : P01 AG003991
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG005681
Pays : United States
Organisme : LMUexcellent
Pays : International
Organisme : Deutsche Forschungsgemeinschaft (DFG)
ID : HA1737/16-1
Pays : International
Informations de copyright
© 2020 The Authors. Published under the terms of the CC BY 4.0 license.
Références
Mol Neurodegener. 2019 Jan 10;14(1):1
pubmed: 30630532
Science. 2016 May 6;352(6286):712-716
pubmed: 27033548
Nat Rev Neurosci. 2018 Oct;19(10):622-635
pubmed: 30206328
Psychopharmacology (Berl). 2016 May;233(9):1637-50
pubmed: 26847047
. 2017 Jul;18(7):1186-1198
pubmed: 28483841
EMBO Mol Med. 2020 Sep 7;12(9):e12308
pubmed: 32790063
Brain. 2016 Apr;139(Pt 4):1252-64
pubmed: 26984188
Lancet Neurol. 2012 Aug;11(8):669-78
pubmed: 22749065
Alzheimers Dement. 2018 Apr;14(4):535-562
pubmed: 29653606
EMBO Mol Med. 2017 Oct;9(10):1356-1365
pubmed: 28855300
EMBO J. 2017 Jul 3;36(13):1837-1853
pubmed: 28559417
Neurosci Lett. 2018 Feb 14;666:70-77
pubmed: 29246793
Front Aging Neurosci. 2017 Jan 31;9:8
pubmed: 28197095
J Neuropathol Exp Neurol. 1995 Mar;54(2):276-81
pubmed: 7876895
Cell. 2017 Jun 15;169(7):1276-1290.e17
pubmed: 28602351
Acta Neuropathol. 1997 Jul;94(1):1-5
pubmed: 9224523
J Exp Med. 2005 Feb 21;201(4):647-57
pubmed: 15728241
FASEB J. 2019 Sep;33(9):10425-10442
pubmed: 31219699
N Engl J Med. 2013 Oct 17;369(16):1569-70
pubmed: 24143816
Brain. 2008 Nov;131(Pt 11):3081-91
pubmed: 18790823
J Neurosci. 2018 May 9;38(19):4482-4489
pubmed: 29686045
Neuron. 2018 Mar 7;97(5):1023-1031.e7
pubmed: 29518356
EMBO Mol Med. 2016 Jun 01;8(6):595-608
pubmed: 27025652
Cell. 2015 Mar 12;160(6):1061-71
pubmed: 25728668
Acta Neuropathol Commun. 2016 Dec 12;4(1):130
pubmed: 27955679
Alzheimers Dement (N Y). 2018 Sep 06;4:575-590
pubmed: 30406177
Inflammation. 2018 Jun;41(3):811-823
pubmed: 29362997
Int J Geriatr Psychiatry. 2012 Apr;27(4):364-74
pubmed: 21560159
J Biol Chem. 2015 Jun 19;290(25):15866-77
pubmed: 25957402
Neurobiol Aging. 2015 Dec;36(12):3176-3186
pubmed: 26364736
Lancet Neurol. 2013 Apr;12(4):357-67
pubmed: 23477989
Sci Transl Med. 2019 Aug 28;11(507):
pubmed: 31462511
Neurobiol Aging. 2016 Feb;38:47-55
pubmed: 26827642
J Neurosci. 2020 Feb 26;40(9):1956-1974
pubmed: 31980586
Science. 1992 Apr 10;256(5054):184-5
pubmed: 1566067
Alzheimers Dement (Amst). 2018 Feb 23;10:232-236
pubmed: 29780868
Neurology. 2010 Jan 19;74(3):201-9
pubmed: 20042704
Immunity. 2017 Sep 19;47(3):566-581.e9
pubmed: 28930663
J Neurosci. 2017 Jan 18;37(3):637-647
pubmed: 28100745
Neuron. 2016 May 18;90(4):724-39
pubmed: 27196974
Nat Genet. 2017 Sep;49(9):1373-1384
pubmed: 28714976
Acta Neuropathol. 2019 Oct;138(4):613-630
pubmed: 31350575
Mol Neurodegener. 2017 May 26;12(1):43
pubmed: 28549481
J Nucl Med. 2016 Jun;57(6):954-60
pubmed: 26912428
Neuron. 2018 Mar 7;97(5):1032-1048.e5
pubmed: 29518357
Nat Neurosci. 2013 Dec;16(12):1896-905
pubmed: 24162652
Mol Neurodegener. 2017 Nov 10;12(1):83
pubmed: 29126445
Alzheimers Dement. 2016 Dec;12(12):1259-1272
pubmed: 27423963
Neuron. 2016 Mar 2;89(5):971-982
pubmed: 26938442
Nature. 1995 Apr 13;374(6523):647-50
pubmed: 7715705
Neurobiol Dis. 2016 Jan;85:218-224
pubmed: 26563933
EMBO Mol Med. 2016 May 02;8(5):466-76
pubmed: 26941262
Oxid Med Cell Longev. 2018 Apr 18;2018:4248526
pubmed: 29849895
J Exp Med. 2015 Mar 9;212(3):287-95
pubmed: 25732305
N Engl J Med. 2013 Jan 10;368(2):107-16
pubmed: 23150908
Nat Neurosci. 2019 Feb;22(2):191-204
pubmed: 30617257
J Neuroinflammation. 2013 Sep 18;10:114
pubmed: 24044641
Sci Transl Med. 2019 Aug 14;11(505):
pubmed: 31413141
J Nucl Med. 2015 Apr;56(4):567-74
pubmed: 25745095
J Neurosci. 2006 Oct 4;26(40):10129-40
pubmed: 17021169
JAMA. 2013 Apr 10;309(14):1483-92
pubmed: 23571587
J Clin Invest. 2017 Sep 1;127(9):3240-3249
pubmed: 28862638
Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):11524-11529
pubmed: 29073081
J Nucl Med. 2019 Apr;60(4):548-554
pubmed: 30262517
Neuron. 2019 Sep 4;103(5):820-835.e7
pubmed: 31301936
Nat Neurosci. 2014 May;17(5):661-3
pubmed: 24728269
Front Neurol. 2018 Aug 07;9:625
pubmed: 30131755
EMBO J. 2018 Jan 17;37(2):167-182
pubmed: 29229786
Sci Transl Med. 2016 Dec 14;8(369):369ra178
pubmed: 27974666
N Engl J Med. 2013 Jan 10;368(2):117-27
pubmed: 23150934
Mol Neurodegener. 2016 Jan 12;11:3
pubmed: 26754172
Acta Neuropathol. 2017 Aug;134(2):171-186
pubmed: 28488154
Mol Psychiatry. 2015 Oct;20(10):1179-87
pubmed: 26055427
J Neuroimmunol. 1989 Oct;24(3):173-82
pubmed: 2808689
Nat Neurosci. 2019 Aug;22(8):1217-1222
pubmed: 31235932
. 2006 Sep;7(9):940-6
pubmed: 16906128
Sci Transl Med. 2014 Jul 2;6(243):243ra86
pubmed: 24990881
Nat Genet. 2019 Mar;51(3):404-413
pubmed: 30617256
Brain. 2018 Jun 1;141(6):1855-1870
pubmed: 29608645
Neurobiol Aging. 2019 Mar;75:25-37
pubmed: 30508733
J Nucl Med. 2019 Dec;60(12):1787-1793
pubmed: 31302633
Neuropharmacology. 2016 Jun;105:196-206
pubmed: 26802771
Mol Neurodegener. 2017 Oct 16;12(1):74
pubmed: 29037207
J Nucl Med. 2013 Jul;54(7):1127-34
pubmed: 23729696
Nat Genet. 2009 Oct;41(10):1094-9
pubmed: 19734903
J Neuroinflammation. 2018 Nov 6;15(1):307
pubmed: 30400912
Lancet Neurol. 2018 Mar;17(3):241-250
pubmed: 29397305
Cell. 2013 Apr 25;153(3):707-20
pubmed: 23622250
Acta Neuropathol. 2016 Jun;131(6):925-33
pubmed: 26754641
EMBO Mol Med. 2019 Jun;11(6):
pubmed: 31122931
Neuroimage. 2017 Aug 15;157:448-463
pubmed: 28587897
Nat Commun. 2019 Mar 25;10(1):1365
pubmed: 30911003