Ecdysteroid Derivatives that Reverse P-Glycoprotein-Mediated Drug Resistance.
Journal
Journal of natural products
ISSN: 1520-6025
Titre abrégé: J Nat Prod
Pays: United States
ID NLM: 7906882
Informations de publication
Date de publication:
28 08 2020
28 08 2020
Historique:
pubmed:
14
8
2020
medline:
15
9
2021
entrez:
14
8
2020
Statut:
ppublish
Résumé
The expression of multidrug resistance P-glycoprotein (P-gp) by cancer cells represents one of the major drawbacks to successful cancer therapy. Accordingly, the development of drugs that inhibit the activity of this transporter remains a major challenge in cancer drug discovery. In this context, several new ecdysteroid derivatives have been synthesized and evaluated as P-gp inhibitors. Two of them (compounds
Identifiants
pubmed: 32790992
doi: 10.1021/acs.jnatprod.0c00334
pmc: PMC8009596
doi:
Substances chimiques
ATP Binding Cassette Transporter, Subfamily B
0
ATP-Binding Cassette Transporters
0
Antineoplastic Agents
0
Ecdysteroids
0
Rhodamine 123
1N3CZ14C5O
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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