Serial serum SARS-CoV-2 RNA results in two COVID-19 cases with severe respiratory failure.
Adult
Aged
Betacoronavirus
/ genetics
COVID-19
COVID-19 Testing
Clinical Laboratory Techniques
Coronavirus Infections
/ blood
Humans
Male
Pandemics
Pneumonia, Viral
/ blood
RNA, Viral
/ blood
Respiratory Insufficiency
/ blood
Retrospective Studies
Reverse Transcriptase Polymerase Chain Reaction
SARS-CoV-2
Severity of Illness Index
Time Factors
Viremia
/ complications
COVID-19
Serum SARS-CoV-2 RNA
Severe respiratory failure
Journal
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy
ISSN: 1437-7780
Titre abrégé: J Infect Chemother
Pays: Netherlands
ID NLM: 9608375
Informations de publication
Date de publication:
Nov 2020
Nov 2020
Historique:
received:
06
04
2020
revised:
06
07
2020
accepted:
13
07
2020
pubmed:
15
8
2020
medline:
15
9
2020
entrez:
15
8
2020
Statut:
ppublish
Résumé
Coronavirus disease 2019 (COVID-19) is spreading worldwide and poses an imminent threat to public health. We encountered 2 cases of COVID-19 with progression resulting in severe respiratory failure and improvement without any specific treatment. To examine the course of infection, we performed reverse-transcription (RT) polymerase chain reaction assay with serum specimens, and serum SARS-CoV-2 RNA was detected in both cases when body temperature increased and respiratory status deteriorated. We, then examined, retrospectively and prospectively, the clinical course during hospitalization by performing serial examinations of serum SARS-CoV-2 RNA status. The findings from our cases suggest that not only is detection of viremia useful as a predictive marker of severity, but also serial serum SARS-CoV-2 RNA results can be helpful for predicting the clinical course.
Identifiants
pubmed: 32792249
pii: S1341-321X(20)30216-6
doi: 10.1016/j.jiac.2020.07.003
pmc: PMC7366999
pii:
doi:
Substances chimiques
RNA, Viral
0
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
1220-1223Informations de copyright
Copyright © 2020 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest None.
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