A natural Ala610Val substitution causing glucocorticoid receptor hypersensitivity aggravates consequences of endotoxemia.
Dexamethasone
Endotoxemia
HPA axis
Lipopolysaccharide
Platelets
Journal
Brain, behavior, and immunity
ISSN: 1090-2139
Titre abrégé: Brain Behav Immun
Pays: Netherlands
ID NLM: 8800478
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
07
04
2020
revised:
03
08
2020
accepted:
08
08
2020
pubmed:
17
8
2020
medline:
28
4
2021
entrez:
16
8
2020
Statut:
ppublish
Résumé
Despite the crucial role of glucocorticoid receptor (GR) in proper immune responses, the effect of GR hypersensitivity on inflammation is rarely reported. To fill this knowledge gap, we exploited the natural gain-of-function substitution in the porcine glucocorticoid receptor (GR
Identifiants
pubmed: 32795657
pii: S0889-1591(20)30497-9
doi: 10.1016/j.bbi.2020.08.009
pii:
doi:
Substances chimiques
Lipopolysaccharides
0
Receptors, Glucocorticoid
0
Dexamethasone
7S5I7G3JQL
Adrenocorticotropic Hormone
9002-60-2
Hydrocortisone
WI4X0X7BPJ
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
174-183Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.