β-Cell-Specific Deletion of HMG-CoA (3-hydroxy-3-methylglutaryl-coenzyme A) Reductase Causes Overt Diabetes due to Reduction of β-Cell Mass and Impaired Insulin Secretion.

Animals Basic Helix-Loop-Helix Transcription Factors / genetics Blood Glucose Diabetes Mellitus Feeding Behavior Gene Expression Regulation, Enzymologic / physiology Glucose Tolerance Test Homeodomain Proteins / genetics Hydroxymethylglutaryl CoA Reductases / genetics Hyperglycemia Insulin / blood Insulin-Secreting Cells / enzymology Maf Transcription Factors, Large / genetics Mice Mice, Knockout Nerve Tissue Proteins / genetics Trans-Activators / genetics

Journal

Diabetes
ISSN: 1939-327X
Titre abrégé: Diabetes
Pays: United States
ID NLM: 0372763

Informations de publication

Date de publication:
11 2020
Historique:
received: 09 10 2019
accepted: 03 08 2020
pubmed: 17 8 2020
medline: 26 1 2021
entrez: 16 8 2020
Statut: ppublish

Résumé

Inhibitors of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), statins, which are used to prevent cardiovascular diseases, are associated with a modest increase in the risk of new-onset diabetes. To investigate the role of HMGCR in the development of β-cells and glucose homeostasis, we deleted

Identifiants

DOI: 10.2337/db19-0996 PMID: 32796082
pubmed: 32796082
pii: db19-0996
doi: 10.2337/db19-0996
doi:

Substances chimiques

Basic Helix-Loop-Helix Transcription Factors 0
Blood Glucose 0
Homeodomain Proteins 0
Insulin 0
Maf Transcription Factors, Large 0
Mafa protein, mouse 0
Nerve Tissue Proteins 0
Neurog3 protein, mouse 0
Trans-Activators 0
pancreatic and duodenal homeobox 1 protein 0
Hydroxymethylglutaryl CoA Reductases EC 1.1.1.-
Hmgcr protein, mouse EC 1.1.1.34

Banques de données

figshare
['10.2337/figshare.12771422']

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2352-2363

Informations de copyright

© 2020 by the American Diabetes Association.

Auteurs

Shoko Takei (S)

Division of Endocrinology and Metabolism, Department of Internal Medicine, Jichi Medical University School of Medicine, Shimotsuke, Tochigi, Japan.

Shuichi Nagashima (S)

Division of Endocrinology and Metabolism, Department of Internal Medicine, Jichi Medical University School of Medicine, Shimotsuke, Tochigi, Japan.

Akihito Takei (A)

Division of Endocrinology and Metabolism, Department of Internal Medicine, Jichi Medical University School of Medicine, Shimotsuke, Tochigi, Japan.

Daisuke Yamamuro (D)

Division of Endocrinology and Metabolism, Department of Internal Medicine, Jichi Medical University School of Medicine, Shimotsuke, Tochigi, Japan.

Tetsuji Wakabayashi (T)

Division of Endocrinology and Metabolism, Department of Internal Medicine, Jichi Medical University School of Medicine, Shimotsuke, Tochigi, Japan.

Akiko Murakami (A)

Division of Endocrinology and Metabolism, Department of Internal Medicine, Jichi Medical University School of Medicine, Shimotsuke, Tochigi, Japan.

Masayo Isoda (M)

Division of Endocrinology and Metabolism, Department of Internal Medicine, Jichi Medical University School of Medicine, Shimotsuke, Tochigi, Japan.

Hisataka Yamazaki (H)

Division of Endocrinology and Metabolism, Department of Internal Medicine, Jichi Medical University School of Medicine, Shimotsuke, Tochigi, Japan.

Chihiro Ebihara (C)

Division of Endocrinology and Metabolism, Department of Internal Medicine, Jichi Medical University School of Medicine, Shimotsuke, Tochigi, Japan.

Manabu Takahashi (M)

Division of Endocrinology and Metabolism, Department of Internal Medicine, Jichi Medical University School of Medicine, Shimotsuke, Tochigi, Japan.

Ken Ebihara (K)

Division of Endocrinology and Metabolism, Department of Internal Medicine, Jichi Medical University School of Medicine, Shimotsuke, Tochigi, Japan.
ORCID: 0000-0001-8938-0617

Katsuya Dezaki (K)

Division of Integrative Physiology, Department of Physiology, Jichi Medical University School of Medicine, Shimotsuke, Tochigi, Japan.

Yuki Takayanagi (Y)

Division of Brain and Neurophysiology, Department of Physiology, Jichi Medical University School of Medicine, Shimotsuke, Tochigi, Japan.

Tatsushi Onaka (T)

Division of Brain and Neurophysiology, Department of Physiology, Jichi Medical University School of Medicine, Shimotsuke, Tochigi, Japan.

Ken Fujiwara (K)

Division of Histology and Cell Biology, Department of Anatomy, Jichi Medical University School of Medicine, Shimotsuke, Tochigi, Japan.

Takashi Yashiro (T)

Division of Histology and Cell Biology, Department of Anatomy, Jichi Medical University School of Medicine, Shimotsuke, Tochigi, Japan.

Shun Ishibashi (S)

Division of Endocrinology and Metabolism, Department of Internal Medicine, Jichi Medical University School of Medicine, Shimotsuke, Tochigi, Japan ishibash@jichi.ac.jp.
ORCID: 0000-0002-1063-1979

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › β-Cell-Specific Deletion of HMG-CoA...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription à motif basique hélice-boucle-hélice › β-Cell-Specific Deletion of HMG-CoA...
questionsmedicales.fr › Glucides › Sucres › Oses › Hexose › Glucose › Glycémie › β-Cell-Specific Deletion of HMG-CoA...
questionsmedicales.fr › Maladies endocriniennes › Diabète › β-Cell-Specific Deletion of HMG-CoA...
questionsmedicales.fr › Phénomènes physiologiques › Alimentation et nutrition › Phénomènes physiologiques nutritionnels › Comportement alimentaire › β-Cell-Specific Deletion of HMG-CoA...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes codant pour des enzymes › β-Cell-Specific Deletion of HMG-CoA...
questionsmedicales.fr › Techniques d'investigation › Techniques de laboratoire clinique › Tests de chimie clinique › Analyse chimique du sang › Hyperglycémie provoquée › β-Cell-Specific Deletion of HMG-CoA...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de liaison à l'ADN › Protéines à homéodomaine › β-Cell-Specific Deletion of HMG-CoA...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Alcohol oxidoreductases › NAD (+) and NADP (+) dependent Alcohol oxidoreductases › 3-Hydroxyacyl-CoA dehydrogenases › Hydroxymethylglutaryl-CoA reductases › β-Cell-Specific Deletion of HMG-CoA...
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Troubles du métabolisme du glucose › Hyperglycémie › β-Cell-Specific Deletion of HMG-CoA...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Hormones peptidiques › Hormones pancréatiques › Insulines › Insuline › β-Cell-Specific Deletion of HMG-CoA...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules entéroendocrines › Cellules à insuline › β-Cell-Specific Deletion of HMG-CoA...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription à motif basique et à glissière à leucines › Facteurs de transcription Maf › Grandes protéines des facteurs de transcription Maf › β-Cell-Specific Deletion of HMG-CoA...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › β-Cell-Specific Deletion of HMG-CoA...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › β-Cell-Specific Deletion of HMG-CoA...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › β-Cell-Specific Deletion of HMG-CoA...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines virales › Protéines virales régulatrices ou accessoires › Transactivateurs › β-Cell-Specific Deletion of HMG-CoA...