Segmental Bone Reconstruction by Octacalcium Phosphate Collagen Composites with Teriparatide.
bone regeneration
collagen
octacalcium phosphate
teriparatide
translational medical research
Journal
Tissue engineering. Part A
ISSN: 1937-335X
Titre abrégé: Tissue Eng Part A
Pays: United States
ID NLM: 101466659
Informations de publication
Date de publication:
05 2021
05 2021
Historique:
pubmed:
18
8
2020
medline:
16
10
2021
entrez:
18
8
2020
Statut:
ppublish
Résumé
Octacalcium phosphate and collagen composite (OCPcol) demonstrated superior bone regeneration and has been commercialized recently in Japan. Teriparatide (TPTD) is a bioactive recombinant form of parathyroid hormone that is approved for osteoporosis treatment. Because mandibular bone reconstruction after segmental resection is a key clinical problem, it was examined whether single-dose local administration of OCPcol with TPTD can affect recovery after this procedure. OCPcol was prepared, and a commercially available hydroxyapatite and collagen composite (HAPcol) was used as a control. A 15 mm length segmental bone defect was made in the mandibular region of male beagle dogs. The experimental animals were divided in four groups. OCPcol treated with TPTD (OCPcol + TPTD), OCPcol, HAPcol treated with TPTD (HAPcol + TPTD), or HAPcol was implanted into the defect. The radiopaque areas of the implanted site were measured and statistically analyzed, and histological examination was performed after 6 months. The value of radiopaque area in total region of OCPcol + TPTD was highest (90.8 ± 7.3 mm
Identifiants
pubmed: 32799756
doi: 10.1089/ten.TEA.2020.0150
pmc: PMC8126423
doi:
Substances chimiques
Bone Density Conservation Agents
0
Calcium Phosphates
0
Teriparatide
10T9CSU89I
octacalcium phosphate
13767-12-9
Collagen
9007-34-5
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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