The Effects of Stiffness, Fluid Viscosity, and Geometry of Microenvironment in Homeostasis, Aging, and Diseases: A Brief Review.

Aging Cell Movement Extracellular Matrix Homeostasis Viscosity
ECM architecture aging cancer curvature homeostasis stiffness viscosity

Journal

Journal of biomechanical engineering
ISSN: 1528-8951
Titre abrégé: J Biomech Eng
Pays: United States
ID NLM: 7909584

Informations de publication

Date de publication:
01 10 2020
Historique:
received: 05 03 2020
pubmed: 18 8 2020
medline: 15 12 2021
entrez: 18 8 2020
Statut: ppublish

Résumé

Cells sense biophysical cues in the micro-environment and respond to the cues biochemically and biophysically. Proper responses from cells are critical to maintain the homeostasis in the body. Abnormal biophysical cues will cause pathological development in the cells; pathological or aging cells, on the other hand, can alter their micro-environment to become abnormal. In this minireview, we discuss four important biophysical cues of the micro-environment-stiffness, curvature, extracellular matrix (ECM) architecture and viscosity-in terms of their roles in health, aging, and diseases.

Identifiants

DOI: 10.1115/1.4048110 PMID: 32803227 PMC: PMC7477718
pubmed: 32803227
pii: 1086203
doi: 10.1115/1.4048110
pmc: PMC7477718
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NCI NIH HHS
ID : F99 CA253759
Pays : United States
Organisme : NIH HHS
ID : S10 OD025193
Pays : United States
Organisme : NIBIB NIH HHS
ID : R21 EB029677
Pays : United States
Organisme : NHLBI NIH HHS
ID : F31 HL154709
Pays : United States
Organisme : NIA NIH HHS
ID : T32 AG058527
Pays : United States

Informations de copyright

Copyright © 2020 by ASME.

Auteurs

Seungman Park (S)

Department of Mechanical Engineering, Johns Hopkins University, Baltimore, MD 21218; Center for Cell Dynamics, Johns Hopkins University, Baltimore, MD 21218; Institute for NanoBio Technology, Johns Hopkins University, Baltimore, MD 21218.

Wei-Hung Jung (WH)

Department of Mechanical Engineering, Johns Hopkins University, Baltimore, MD 21218; Center for Cell Dynamics, Johns Hopkins University, Baltimore, MD 21218; Department of Mechanical Engineering, Institute for NanoBio Technology, Johns Hopkins University, Baltimore, MD 21218.

Matthew Pittman (M)

Department of Mechanical Engineering, Johns Hopkins University, Baltimore, MD 21218; Center for Cell Dynamics, Johns Hopkins University, Baltimore, MD 21218; Department of Mechanical Engineering, Institute for NanoBio Technology, Johns Hopkins University, Baltimore, MD 21218.

Junjie Chen (J)

Department of Mechanical Engineering, Johns Hopkins University, Baltimore, MD 21218; Center for Cell Dynamics, Johns Hopkins University, Baltimore, MD 21218; Department of Mechanical Engineering, Institute for NanoBio Technology, Johns Hopkins University, Baltimore, MD 21218.

Yun Chen (Y)

Department of Mechanical Engineering, Johns Hopkins University, Baltimore, MD 21218; Center for Cell Dynamics, Johns Hopkins University, Baltimore, MD 21218; Department of Mechanical Engineering, Institute for NanoBio Technology, Johns Hopkins University, Baltimore, MD 21218.

Articles similaires

Pathogenic mitochondrial DNA mutations inhibit melanoma metastasis.

Spencer D Shelton, Sara House, Luiza Martins Nascentes Melo et al.
1.00
DNA, Mitochondrial Humans Melanoma Mutation Neoplasm Metastasis

Dose response of leisure time physical activity and biological aging in type 2 diabetes: a cross sectional study.

Dongzhe Wu, Yishuai Jia, Yujia Liu et al.
1.00
Humans Diabetes Mellitus, Type 2 Male Female Exercise

The association between sleep duration trajectories and successful aging: a population-based cohort study.

Liuhong Tian, Pan Ding, Xiaodan Kuang et al.
1.00
Humans Male Female Aged Middle Aged

A scenario for an evolutionary selection of ageing.

Tristan Roget, Claire Macmurray, Pierre Jolivet et al.
1.00
Aging Selection, Genetic Biological Evolution Animals Fertility

Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › The Effects of Stiffness, Fluid Viscosity, and...
questionsmedicales.fr › Phénomènes physiologiques › Mouvement cellulaire › The Effects of Stiffness, Fluid Viscosity, and...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace extracellulaire › Matrice extracellulaire › The Effects of Stiffness, Fluid Viscosity, and...
questionsmedicales.fr › Phénomènes physiologiques › Homéostasie › The Effects of Stiffness, Fluid Viscosity, and...
questionsmedicales.fr › Phénomènes chimiques › Viscosité › The Effects of Stiffness, Fluid Viscosity, and...