Exposure to the herbicide 2,4-dichlorophenoxyacetic acid impairs mitochondrial function, oxidative status, and behavior in adult zebrafish.
2,4-D
Behavior
Herbicides
Mitochondrial energy metabolism
Oxidative status
Zebrafish
Journal
Environmental science and pollution research international
ISSN: 1614-7499
Titre abrégé: Environ Sci Pollut Res Int
Pays: Germany
ID NLM: 9441769
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
received:
25
05
2020
accepted:
12
08
2020
pubmed:
18
8
2020
medline:
27
11
2020
entrez:
18
8
2020
Statut:
ppublish
Résumé
2,4-Dichlorophenoxyacetic acid (2,4-D) is one of the most commonly used herbicides worldwide. While the effects of 2,4-D in target organisms are well known, its consequences in nontarget organisms are not fully explained. Therefore, the purpose of this study was to investigate the effects of the herbicide on mitochondrial energy metabolism, oxidative status, and exploratory behavior in adult zebrafish. Animal exposure to 2,4-D increased cytochrome c oxidase and catalase activities and reduced SOD/CAT ratio, moreover, increased the total distance traveled and the number of crossings. Finally, animals exposed to 2,4-D spent more time in the upper zone of the tank and traveled a long distance in the upper zone. Overall, our results indicate the 2,4-D can provoke disabling effects in nontarget organisms. The obtained data showed that exposure to 2,4-D at environmentally relevant concentrations alters mitochondrial metabolism and antioxidant status and disturbs the zebrafish innate behavior.
Identifiants
pubmed: 32803608
doi: 10.1007/s11356-020-10497-6
pii: 10.1007/s11356-020-10497-6
doi:
Substances chimiques
Herbicides
0
2,4-Dichlorophenoxyacetic Acid
2577AQ9262
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
45874-45882Références
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