Association of inflammatory mediators with frailty status in older adults: results from a systematic review and meta-analysis.
C-reactive protein
Frailty
Inflammaging
Interleukin 6
Older adults
Tumor necrosis factor alpha
Journal
GeroScience
ISSN: 2509-2723
Titre abrégé: Geroscience
Pays: Switzerland
ID NLM: 101686284
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
30
03
2020
accepted:
30
07
2020
pubmed:
18
8
2020
medline:
28
4
2021
entrez:
18
8
2020
Statut:
ppublish
Résumé
Frailty is a geriatric syndrome defined as a status of extreme vulnerability to stressors, leading to a higher risk of negative health-related outcomes. "Inflammaging", an age-related state of low-grade chronic inflammation, is characterized by an increased concentration of pro-inflammatory cytokines and acute phase proteins. Inflammaging has been postulated as an underlying mechanism of frailty, and several studies tested the relationship between frailty and concentration of inflammatory mediators. The aim of this systematic review and meta-analysis was to test whether inflammatory mediators are overproduced in frail older adults. Among the 758 articles identified in the literature search, 50 were included in the systematic review, and 39 in the three meta-analyses, i.e., C-reactive protein (CRP), interleukin 6 (IL6), and tumor necrosis factor α. To reduce heterogeneity, meta-analyses were restricted to studies identifying frailty by the Fried et al. [1] [J. Gerontol. A. Biol. Sci. Med. Sci. 56, M146-56] phenotypic criteria. Quantitative analyses measuring the association between frailty and biomarker concentrations showed significant differences when frail subjects were compared to non-frail and pre-frail subjects for CRP and IL6. This work established strong association between inflammatory biomarkers and frailty, confirming the role of age-related chronic inflammation in frailty development.
Identifiants
pubmed: 32803650
doi: 10.1007/s11357-020-00247-4
pii: 10.1007/s11357-020-00247-4
pmc: PMC7732924
doi:
Substances chimiques
Biomarkers
0
Inflammation Mediators
0
C-Reactive Protein
9007-41-4
Types de publication
Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Review
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
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