Hox
SHF
cardiac differentiation
congenital heart defect
developmental biology
heart development
mouse
progenitor cell
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
17 08 2020
17 08 2020
Historique:
received:
13
01
2020
accepted:
16
08
2020
pubmed:
18
8
2020
medline:
12
2
2021
entrez:
18
8
2020
Statut:
epublish
Résumé
Perturbation of addition of second heart field (SHF) cardiac progenitor cells to the poles of the heart tube results in congenital heart defects (CHD). The transcriptional programs and upstream regulatory events operating in different subpopulations of the SHF remain unclear. Here, we profile the transcriptome and chromatin accessibility of anterior and posterior SHF sub-populations at genome-wide levels and demonstrate that Hoxb1 negatively regulates differentiation in the posterior SHF. Spatial mis-expression of
Identifiants
pubmed: 32804075
doi: 10.7554/eLife.55124
pii: 55124
pmc: PMC7462617
doi:
pii:
Substances chimiques
Chromatin
0
HOXB1 homeodomain protein
0
Homeodomain Proteins
0
Banques de données
GEO
['GSE123765', 'GSE123771', 'GSE123773']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Agence Nationale de la Recherche
ID : ANR-13-BSV2-0003
Pays : International
Organisme : Agence Nationale de la Recherche
ID : ANR-18-CE13-0011
Pays : International
Organisme : Association Française contre les Myopathies
ID : MNH-Decrypt
Pays : International
Organisme : Fondation pour la Recherche Médicale
ID : DEQ20150331717
Pays : International
Organisme : European Commission
ID : H2020-MSCA-IF-2014
Pays : International
Informations de copyright
© 2020, Stefanovic et al.
Déclaration de conflit d'intérêts
SS, BL, JD, FL, LA, CM, DS, EP, CD, KP, MT, CB, MP, AG, RK, SZ No competing interests declared
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