Monocyte Subsets With High Osteoclastogenic Potential and Their Epigenetic Regulation Orchestrated by IRF8.

Animals Cell Differentiation Epigenesis, Genetic Interferon Regulatory Factors / genetics Mice Monocytes / metabolism NFATC Transcription Factors / genetics Osteoclasts / metabolism Osteogenesis / genetics RANK Ligand / metabolism
BONE MARROW ChIP-seq IRF8 LY6C MACROPHAGE MONOCYTE OSTEOCLAST RANK RANKL RNA-seq

Journal

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
ISSN: 1523-4681
Titre abrégé: J Bone Miner Res
Pays: United States
ID NLM: 8610640

Informations de publication

Date de publication:
01 2021
Historique:
received: 26 06 2020
revised: 21 07 2020
accepted: 05 08 2020
pubmed: 18 8 2020
medline: 29 7 2021
entrez: 18 8 2020
Statut: ppublish

Résumé

Osteoclasts (OCs) are bone-resorbing cells formed by the serial fusion of monocytes. In mice and humans, three distinct subsets of monocytes exist; however, it is unclear if all of them exhibit osteoclastogenic potential. Here we show that in wild-type (WT) mice, Ly6C

Identifiants

DOI: 10.1002/jbmr.4165 PMID: 32804442 PMC: PMC8168257
pubmed: 32804442
doi: 10.1002/jbmr.4165
pmc: PMC8168257
mid: NIHMS1707355
doi:

Substances chimiques

Interferon Regulatory Factors 0
NFATC Transcription Factors 0
RANK Ligand 0
interferon regulatory factor-8 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

199-214

Subventions

Organisme : NIDCR NIH HHS
ID : K99 DE028439
Pays : United States
Organisme : NIDCR NIH HHS
ID : R00 DE028439
Pays : United States
Organisme : NIDCR NIH HHS
ID : R01 DE027639
Pays : United States
Organisme : NIDCR NIH HHS
ID : R03 DE029258
Pays : United States

Informations de copyright

© 2020 American Society for Bone and Mineral Research (ASBMR).

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Auteurs

Amitabh Das (A)

Division of Periodontology, University of Maryland School of Dentistry, Baltimore, MD, USA.
Laboratory of Oral and Connective Tissue Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), Bethesda, MD, USA.

Xiaobei Wang (X)

Division of Periodontology, University of Maryland School of Dentistry, Baltimore, MD, USA.
Laboratory of Oral and Connective Tissue Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), Bethesda, MD, USA.

Jessica Kang (J)

Division of Periodontology, University of Maryland School of Dentistry, Baltimore, MD, USA.

Alyssa Coulter (A)

Laboratory of Oral and Connective Tissue Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), Bethesda, MD, USA.

Amol C Shetty (AC)

Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.

Mahesh Bachu (M)

Molecular Genetics of Immunity Section, Division of Developmental Biology, National Institute of Child Health and Human Development (NICHD), Bethesda, MD, USA.
Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY, USA.

Stephen R Brooks (SR)

Biodata Mining and Discovery Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), Bethesda, MD, USA.

Stefania Dell'Orso (S)

Biodata Mining and Discovery Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), Bethesda, MD, USA.

Brian L Foster (BL)

Division of Biosciences, College of Dentistry, The Ohio State University, Columbus, OH, USA.

Xiaoxuan Fan (X)

Flow Cytometry Shared Service, University of Maryland School of Medicine, Baltimore, MD, USA.

Keiko Ozato (K)

Molecular Genetics of Immunity Section, Division of Developmental Biology, National Institute of Child Health and Human Development (NICHD), Bethesda, MD, USA.

Martha J Somerman (MJ)

Laboratory of Oral and Connective Tissue Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), Bethesda, MD, USA.

Vivek Thumbigere-Math (V)

Division of Periodontology, University of Maryland School of Dentistry, Baltimore, MD, USA.
Laboratory of Oral and Connective Tissue Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), Bethesda, MD, USA.
ORCID: 0000-0002-8279-3766

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Monocyte Subsets With High Osteoclastogenic...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › Monocyte Subsets With High Osteoclastogenic...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › Monocyte Subsets With High Osteoclastogenic...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de régulation d'interféron › Monocyte Subsets With High Osteoclastogenic...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Monocyte Subsets With High Osteoclastogenic...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Monocytes › Monocyte Subsets With High Osteoclastogenic...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription NFATC › Monocyte Subsets With High Osteoclastogenic...
questionsmedicales.fr › Cellules › Cellules myéloïdes › Ostéoclastes › Monocyte Subsets With High Osteoclastogenic...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système locomoteur › Développement locomoteur › Biominéralisation › Développement osseux › Ostéogenèse › Monocyte Subsets With High Osteoclastogenic...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Facteurs de nécrose tumorale › Ligand de RANK › Monocyte Subsets With High Osteoclastogenic...