Association of Established Blood Pressure Loci With 10-Year Change in Blood Pressure and Their Ability to Predict Incident Hypertension.
Blood Pressure
/ genetics
Female
Genetic Loci
Genetic Predisposition to Disease
Genetic Variation
Genome-Wide Association Study
Guidelines as Topic
Humans
Hypertension
/ epidemiology
Incidence
Male
Middle Aged
Odds Ratio
Predictive Value of Tests
Prospective Studies
ROC Curve
Risk Factors
Sweden
Time Factors
association
blood pressure
genetics
hypertension
incidence
prediction
Journal
Journal of the American Heart Association
ISSN: 2047-9980
Titre abrégé: J Am Heart Assoc
Pays: England
ID NLM: 101580524
Informations de publication
Date de publication:
18 08 2020
18 08 2020
Historique:
pubmed:
18
8
2020
medline:
10
3
2021
entrez:
18
8
2020
Statut:
ppublish
Résumé
Background Genome-wide association studies have identified >1000 genetic variants cross-sectionally associated with blood pressure variation and prevalent hypertension. These discoveries might aid the early identification of subpopulations at risk of developing hypertension or provide targets for drug development, amongst other applications. The aim of the present study was to analyze the association of blood pressure-associated variants with long-term changes (10 years) in blood pressure and also to assess their ability to predict hypertension incidence compared with traditional risk variables in a Swedish population. Methods and Results We constructed 6 genetic risk scores (GRSs) by summing the dosage of the effect allele at each locus of genetic variants previously associated with blood pressure traits (systolic blood pressure GRS (GRS
Identifiants
pubmed: 32805198
doi: 10.1161/JAHA.119.014513
pmc: PMC7660819
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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