Prenatal exposure to organophosphate pesticides and brain morphology and white matter microstructure in preadolescents.
Brain morphology
MRI
Organophosphate pesticides
Prenatal exposure
White matter microstructure
Journal
Environmental research
ISSN: 1096-0953
Titre abrégé: Environ Res
Pays: Netherlands
ID NLM: 0147621
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
23
05
2020
revised:
07
08
2020
accepted:
07
08
2020
pubmed:
18
8
2020
medline:
12
1
2021
entrez:
18
8
2020
Statut:
ppublish
Résumé
Prenatal exposure to organophosphate (OP) pesticides associate with impaired neurodevelopment in humans and animal models. However, much uncertainty exists about the brain structural alterations underlying these associations. The objective of this study was to determine whether maternal OP pesticide metabolite concentrations in urine repeatedly measured during gestation are associated with brain morphology and white matter microstructure in 518 preadolescents aged 9-12 years. Data came from 518 mother-child pairs participating in the Generation R Study, a population-based birth cohort from Rotterdam, the Netherlands. Maternal urine concentrations were determined for 6 dialkylphosphates (DAPs) including 3 dimethyl (DM) and 3 diethyl (DE) alkyl phosphate metabolites, collected at early, mid, and late pregnancy. At child's age 9-12 years, magnetic resonance imaging was performed to obtain T1-weighted images for brain volumes and surface-based cortical thickness and cortical surface area, and diffusion tensor imaging was used to measure white matter microstructure through fractional anisotropy (FA) and mean diffusivity (MD). Linear regression models were fit for the averaged prenatal exposure across pregnancy. DM and DE metabolite concentrations were not associated with brain volumes, cortical thickness, and cortical surface area. However, a 10-fold increase in averaged DM metabolite concentrations across pregnancy was associated with lower FA (B = -1.00, 95%CI = -1.80, -0.20) and higher MD (B = 0.13, 95%CI = 0.04, 0.21). Similar associations were observed for DE concentrations. This study provides the first evidence that OP pesticides may alter normal white matter microstructure in children, which could have consequences for normal neurodevelopment. No associations were observed with structural brain morphology, including brain volumes, cortical thickness, and cortical surface area.
Sections du résumé
BACKGROUND
Prenatal exposure to organophosphate (OP) pesticides associate with impaired neurodevelopment in humans and animal models. However, much uncertainty exists about the brain structural alterations underlying these associations. The objective of this study was to determine whether maternal OP pesticide metabolite concentrations in urine repeatedly measured during gestation are associated with brain morphology and white matter microstructure in 518 preadolescents aged 9-12 years.
METHOD
Data came from 518 mother-child pairs participating in the Generation R Study, a population-based birth cohort from Rotterdam, the Netherlands. Maternal urine concentrations were determined for 6 dialkylphosphates (DAPs) including 3 dimethyl (DM) and 3 diethyl (DE) alkyl phosphate metabolites, collected at early, mid, and late pregnancy. At child's age 9-12 years, magnetic resonance imaging was performed to obtain T1-weighted images for brain volumes and surface-based cortical thickness and cortical surface area, and diffusion tensor imaging was used to measure white matter microstructure through fractional anisotropy (FA) and mean diffusivity (MD). Linear regression models were fit for the averaged prenatal exposure across pregnancy.
RESULTS
DM and DE metabolite concentrations were not associated with brain volumes, cortical thickness, and cortical surface area. However, a 10-fold increase in averaged DM metabolite concentrations across pregnancy was associated with lower FA (B = -1.00, 95%CI = -1.80, -0.20) and higher MD (B = 0.13, 95%CI = 0.04, 0.21). Similar associations were observed for DE concentrations.
CONCLUSIONS
This study provides the first evidence that OP pesticides may alter normal white matter microstructure in children, which could have consequences for normal neurodevelopment. No associations were observed with structural brain morphology, including brain volumes, cortical thickness, and cortical surface area.
Identifiants
pubmed: 32805249
pii: S0013-9351(20)30944-0
doi: 10.1016/j.envres.2020.110047
pmc: PMC7657967
mid: NIHMS1622339
pii:
doi:
Substances chimiques
Organophosphates
0
Pesticides
0
Types de publication
Journal Article
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
110047Subventions
Organisme : NIEHS NIH HHS
ID : HHSN273201500003C
Pays : United States
Organisme : NIEHS NIH HHS
ID : HHSN273201500003O
Pays : United States
Organisme : NIDA NIH HHS
ID : UG3 DA045251
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
Références
Environ Int. 2019 Oct;131:105002
pubmed: 31369979
Neuroimage. 2018 Nov 15;182:207-218
pubmed: 29305910
Environ Health Perspect. 2005 Apr;113(4):494-8
pubmed: 15811842
J Neurosci. 2009 Apr 1;29(13):4263-73
pubmed: 19339620
Ther Drug Monit. 2007 Apr;29(2):150-63
pubmed: 17417068
Environ Health Perspect. 2003 May;111(5):749-56
pubmed: 12727605
Science. 2010 Nov 5;330(6005):779-82
pubmed: 21051629
Toxicology. 2018 Jan 15;393:90-101
pubmed: 29108742
Neuroimage. 2015 Oct 1;119:119-28
pubmed: 26067345
Crit Rev Toxicol. 2008;38 Suppl 2:1-125
pubmed: 18726789
Neurotherapeutics. 2007 Jul;4(3):316-29
pubmed: 17599699
Clin Toxicol (Phila). 2011 Nov;49(9):771-81
pubmed: 22077242
Am J Clin Nutr. 2012 Jun;95(6):1413-21
pubmed: 22572645
Neurotoxicology. 2015 May;48:9-20
pubmed: 25704171
Neuroscience. 2014 Sep 12;276:48-71
pubmed: 24378955
Pharmacol Ther. 2012 Jun;134(3):355-65
pubmed: 22465060
Nat Rev Neurosci. 2018 Feb 16;19(3):123-137
pubmed: 29449712
Environ Sci Pollut Res Int. 2019 Jun;26(18):18267-18290
pubmed: 31041704
Toxicol Appl Pharmacol. 2009 Oct 15;240(2):143-8
pubmed: 19631231
Toxicol Sci. 2006 Aug;92(2):500-6
pubmed: 16675515
Brain Res Bull. 2007 May 30;72(4-6):232-74
pubmed: 17452286
Proc Natl Acad Sci U S A. 2019 Sep 10;116(37):18347-18356
pubmed: 31451641
Dialogues Clin Neurosci. 2013 Sep;15(3):359-84
pubmed: 24174907
Brain Res Dev Brain Res. 2004 Feb 20;148(2):197-206
pubmed: 14766197
Am J Psychiatry. 2018 Jan 1;175(1):54-62
pubmed: 28817944
Environ Health Perspect. 2008 Mar;116(3):340-8
pubmed: 18335101
Brain Res Dev Brain Res. 2005 Mar 22;155(1):71-80
pubmed: 15763277
Epidemiology. 2016 May;27(3):378-88
pubmed: 27035688
Environ Health Perspect. 2003 Dec;111(16):1939-46
pubmed: 14644670
Int J Epidemiol. 2016 Dec 1;45(6):1887-1894
pubmed: 28089956
Environ Res. 2000 Nov;84(3):290-302
pubmed: 11097803
Regul Toxicol Pharmacol. 2003 Jun;37(3):382-95
pubmed: 12758218
Environ Health Perspect. 2003 Nov;111(14):1779-82
pubmed: 14594631
Transl Psychiatry. 2019 Dec 9;9(1):332
pubmed: 31819038
Proc Natl Acad Sci U S A. 2012 May 15;109(20):7871-6
pubmed: 22547821
Eur J Epidemiol. 2016 Dec;31(12):1243-1264
pubmed: 28070760
J Expo Anal Environ Epidemiol. 2004 May;14(3):249-59
pubmed: 15141154
Environ Res. 2004 Nov;96(3):283-9
pubmed: 15364595
J Expo Sci Environ Epidemiol. 2008 Mar;18(2):167-74
pubmed: 17495869
Environ Health Perspect. 2002 May;110(5):549-53
pubmed: 12003762
J Child Psychol Psychiatry. 2016 Jul;57(7):775-93
pubmed: 26987761
NMR Biomed. 2019 Apr;32(4):e3778
pubmed: 28886240
Environ Health Perspect. 2008 Apr;116(4):537-42
pubmed: 18414640
Alzheimers Dement. 2015 Mar;11(3):321-30
pubmed: 25217294
Environ Health Perspect. 2000 Jun;108 Suppl 3:511-33
pubmed: 10852851
Front Psychiatry. 2019 Sep 24;10:696
pubmed: 31607968
Int Arch Occup Environ Health. 2006 Aug;79(7):568-77
pubmed: 16491402
Int J Hyg Environ Health. 2018 Apr;221(3):489-501
pubmed: 29499913
Front Biosci. 2008 Jan 01;13:1240-9
pubmed: 17981626