TERT promoter mutations in primary and secondary WHO grade III meningioma.
TERT promoter mutations
malignant meningioma
malignant progression
meningioma
Journal
Brain pathology (Zurich, Switzerland)
ISSN: 1750-3639
Titre abrégé: Brain Pathol
Pays: Switzerland
ID NLM: 9216781
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
24
05
2020
revised:
03
08
2020
accepted:
10
08
2020
pubmed:
18
8
2020
medline:
21
12
2021
entrez:
18
8
2020
Statut:
ppublish
Résumé
TERT promoter mutation (TERTp We gathered material from a consecutive single-center cohort of 40 patients with malignant meningioma (WHO grade III) treated between 2000 and 2018, including specimens from primary and secondary malignant meningiomas with the corresponding earlier benign specimens and later malignant recurrences. In total 107 tumor samples were studied by Sanger sequencing for TERT promoter mutational status. Seven of 40 patients (17.5%) harbored TERTp TERTp
Identifiants
pubmed: 32805769
doi: 10.1111/bpa.12892
pmc: PMC8018144
doi:
Substances chimiques
TERT protein, human
EC 2.7.7.49
Telomerase
EC 2.7.7.49
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
61-69Subventions
Organisme : Kraeftens Bekaempelse
ID : R214-A12839
Informations de copyright
© 2020 International Society of Neuropathology.
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