DNA Phosphorothioate Modifications Are Widely Distributed in the Human Microbiome.
DNA modification
DNA phosphorothioation
gut microbiome
microbiome
Journal
Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414
Informations de publication
Date de publication:
12 08 2020
12 08 2020
Historique:
received:
10
07
2020
revised:
07
08
2020
accepted:
10
08
2020
entrez:
19
8
2020
pubmed:
19
8
2020
medline:
16
6
2021
Statut:
epublish
Résumé
The DNA phosphorothioate (PT) modification existing in many prokaryotes, including bacterial pathogens and commensals, confers multiple characteristics, including restricting gene transfer, influencing the global transcriptional response, and reducing fitness during exposure to chemical mediators of inflammation. While PT-containing bacteria have been investigated in a variety of environments, they have not been studied in the human microbiome. Here, we investigated the distribution of PT-harboring strains and verified their existence in the human microbiome. We found over 2000 PT gene-containing strains distributed in different body sites, especially in the gastrointestinal tract. PT-modifying genes are preferentially distributed within several genera, including
Identifiants
pubmed: 32806589
pii: biom10081175
doi: 10.3390/biom10081175
pmc: PMC7464106
pii:
doi:
Substances chimiques
Bacterial Proteins
0
DNA, Bacterial
0
Phosphates
0
thiophosphoric acid
TYM4M7EWCW
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Natural Science Foundation of China
ID : 31630002
Pays : International
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