Integrative Modeling of Quantitative Plasma Lipoprotein, Metabolic, and Amino Acid Data Reveals a Multiorgan Pathological Signature of SARS-CoV-2 Infection.

Aged Amino Acids / blood Betacoronavirus Biomarkers Blood Glucose / analysis COVID-19 Coronavirus Infections / blood Female Humans Lipoproteins / blood Magnetic Resonance Spectroscopy Male Mass Spectrometry Metabolome Middle Aged Models, Biological Multiple Organ Failure / blood Pandemics Pneumonia, Viral / blood SARS-CoV-2
COVID-19 NMR spectroscopy SARS-CoV-2 amino acids biomarkers lipoproteins mass spectrometry metabolic phenotyping mosaic disease multiorgan damage systems model

Journal

Journal of proteome research
ISSN: 1535-3907
Titre abrégé: J Proteome Res
Pays: United States
ID NLM: 101128775

Informations de publication

Date de publication:
06 11 2020
Historique:
pubmed: 19 8 2020
medline: 1 12 2020
entrez: 19 8 2020
Statut: ppublish

Résumé

The metabolic effects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on human blood plasma were characterized using multiplatform metabolic phenotyping with nuclear magnetic resonance (NMR) spectroscopy and liquid chromatography-mass spectrometry (LC-MS). Quantitative measurements of lipoprotein subfractions, α-1-acid glycoprotein, glucose, and biogenic amines were made on samples from symptomatic coronavirus disease 19 (COVID-19) patients who had tested positive for the SARS-CoV-2 virus (

Identifiants

DOI: 10.1021/acs.jproteome.0c00519 PMID: 32806897
pubmed: 32806897
doi: 10.1021/acs.jproteome.0c00519
doi:

Substances chimiques

Amino Acids 0
Biomarkers 0
Blood Glucose 0
Lipoproteins 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

4442-4454

Commentaires et corrections

Type : ErratumIn

Auteurs

Torben Kimhofer (T)

Australian National Phenome Centre, Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth, Western Australia 6150, Australia.
ORCID: 0000-0001-7158-9930

Samantha Lodge (S)

Australian National Phenome Centre, Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth, Western Australia 6150, Australia.

Luke Whiley (L)

Australian National Phenome Centre, Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth, Western Australia 6150, Australia.
Perron Institute for Neurological and Translational Science, Nedlands, Western Australia 6009, Australia.
ORCID: 0000-0002-9088-4799

Nicola Gray (N)

Australian National Phenome Centre, Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth, Western Australia 6150, Australia.
ORCID: 0000-0002-0094-5245

Ruey Leng Loo (RL)

Australian National Phenome Centre, Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth, Western Australia 6150, Australia.
ORCID: 0000-0001-5307-5709

Nathan G Lawler (NG)

Australian National Phenome Centre, Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth, Western Australia 6150, Australia.
ORCID: 0000-0001-9649-425X

Philipp Nitschke (P)

Australian National Phenome Centre, Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth, Western Australia 6150, Australia.

Sze-How Bong (SH)

Australian National Phenome Centre, Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth, Western Australia 6150, Australia.

David L Morrison (DL)

Australian National Phenome Centre, Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth, Western Australia 6150, Australia.

Sofina Begum (S)

Section for Nutrition Research, Imperial College London, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, U.K.

Toby Richards (T)

Medical School, Faculty of Health and Medical Sciences, University of Western Australia, and Department of Endocrinology and Diabetes, Fiona Stanley Hospital, Harry Perkins Building, Murdoch, Perth, Western Australia 6150, Australia.

Bu B Yeap (BB)

Medical School, Faculty of Health and Medical Sciences, University of Western Australia, and Department of Endocrinology and Diabetes, Fiona Stanley Hospital, Harry Perkins Building, Murdoch, Perth, Western Australia 6150, Australia.

Chris Smith (C)

The Cambridge Institute of Therapeutic Immunology and Infectious Disease, Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 0QQ, U.K.

Kenneth G C Smith (KGC)

The Cambridge Institute of Therapeutic Immunology and Infectious Disease, Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 0QQ, U.K.

Elaine Holmes (E)

Australian National Phenome Centre, Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth, Western Australia 6150, Australia.
Section for Nutrition Research, Imperial College London, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, U.K.
ORCID: 0000-0002-0556-8389

Jeremy K Nicholson (JK)

Australian National Phenome Centre, Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth, Western Australia 6150, Australia.
Medical School, Faculty of Health and Medical Sciences, University of Western Australia, and Department of Endocrinology and Diabetes, Fiona Stanley Hospital, Harry Perkins Building, Murdoch, Perth, Western Australia 6150, Australia.
Institute of Global Health Innovation, Imperial College London, Level 1, Faculty Building South Kensington Campus, London SW7 2AZ, U.K.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Integrative Modeling of Quantitative Plasma...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Integrative Modeling of Quantitative Plasma...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Nidovirales › Coronaviridae › Coronavirus › Betacoronavirus › Integrative Modeling of Quantitative Plasma...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Integrative Modeling of Quantitative Plasma...
questionsmedicales.fr › Glucides › Sucres › Oses › Hexose › Glucose › Glycémie › Integrative Modeling of Quantitative Plasma...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Pneumopathie virale › COVID-19 › Integrative Modeling of Quantitative Plasma...
questionsmedicales.fr › Infection › Maladies virales › Infections à virus à ARN › Infections à Nidovirales › Infections à Coronaviridae › Infections à coronavirus › Integrative Modeling of Quantitative Plasma...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Integrative Modeling of Quantitative Plasma...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Lipoprotéines › Integrative Modeling of Quantitative Plasma...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Analyse spectrale › Spectroscopie par résonance magnétique › Integrative Modeling of Quantitative Plasma...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Spectrométrie de masse › Integrative Modeling of Quantitative Plasma...
questionsmedicales.fr › Métabolisme › Métabolome › Integrative Modeling of Quantitative Plasma...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Integrative Modeling of Quantitative Plasma...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Integrative Modeling of Quantitative Plasma...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Choc › Défaillance multiviscérale › Integrative Modeling of Quantitative Plasma...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Épidémies de maladies › Épidémies › Pandémies › Integrative Modeling of Quantitative Plasma...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Pneumopathie virale › Integrative Modeling of Quantitative Plasma...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Nidovirales › Coronaviridae › Coronavirus › Betacoronavirus › Virus du SRAS › SARS-CoV-2 › Integrative Modeling of Quantitative Plasma...