Pericardial fat and its influence on cardiac diastolic function.
Adipose Tissue
/ diagnostic imaging
Adiposity
Adult
Aged
Asymptomatic Diseases
Computed Tomography Angiography
Coronary Angiography
Cross-Sectional Studies
Diastole
Echocardiography
Female
Humans
Male
Middle Aged
Pericardium
Retrospective Studies
Risk Assessment
Risk Factors
Ventricular Dysfunction, Left
/ diagnostic imaging
Ventricular Function, Left
Cardiac diastolic function
Epicardial fat
Pericardial fat
Journal
Cardiovascular diabetology
ISSN: 1475-2840
Titre abrégé: Cardiovasc Diabetol
Pays: England
ID NLM: 101147637
Informations de publication
Date de publication:
17 08 2020
17 08 2020
Historique:
received:
01
04
2020
accepted:
25
07
2020
entrez:
19
8
2020
pubmed:
19
8
2020
medline:
18
5
2021
Statut:
epublish
Résumé
Pericardial fat (PF) has been suggested to directly act on cardiomyocytes, leading to diastolic dysfunction. The aim of this study was to investigate whether a higher PF volume is associated with a lower diastolic function in healthy subjects. 254 adults (40-70 years, BMI 18-35 kg/m Significant associations for all four diastolic parameters with the PF volume were found after adjusting for BMI, age, and sex. In addition, subjects with high pericardial fat had a reduced left atrial volume index (p = 0.02), lower E/e (p < 0.01) and E/A (p = 0.01), reduced e' lateral (p < 0.01), reduced e' septal p = 0.03), compared to subjects with low pericardial fat. These findings confirm that pericardial fat volume, even in healthy subjects with normal cardiac function, is associated with diastolic function. Our results suggest that the mechanical effects of PF may limit the distensibility of the heart and thereby directly contribute to diastolic dysfunction. Trial registration NCT01671930.
Sections du résumé
BACKGROUND
Pericardial fat (PF) has been suggested to directly act on cardiomyocytes, leading to diastolic dysfunction. The aim of this study was to investigate whether a higher PF volume is associated with a lower diastolic function in healthy subjects.
METHODS
254 adults (40-70 years, BMI 18-35 kg/m
RESULTS
Significant associations for all four diastolic parameters with the PF volume were found after adjusting for BMI, age, and sex. In addition, subjects with high pericardial fat had a reduced left atrial volume index (p = 0.02), lower E/e (p < 0.01) and E/A (p = 0.01), reduced e' lateral (p < 0.01), reduced e' septal p = 0.03), compared to subjects with low pericardial fat.
CONCLUSION
These findings confirm that pericardial fat volume, even in healthy subjects with normal cardiac function, is associated with diastolic function. Our results suggest that the mechanical effects of PF may limit the distensibility of the heart and thereby directly contribute to diastolic dysfunction. Trial registration NCT01671930.
Identifiants
pubmed: 32807203
doi: 10.1186/s12933-020-01097-2
pii: 10.1186/s12933-020-01097-2
pmc: PMC7430122
doi:
Banques de données
ClinicalTrials.gov
['NCT01671930']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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