Mesenchymal stromal cells for sepsis and septic shock: Lessons for treatment of COVID-19.
COVID-19
Wharton's Jelly
acute respiratory distress syndrome
mesenchymal stromal/stem cells
sepsis
Journal
Stem cells translational medicine
ISSN: 2157-6580
Titre abrégé: Stem Cells Transl Med
Pays: England
ID NLM: 101578022
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
04
06
2020
revised:
06
07
2020
accepted:
12
07
2020
pubmed:
19
8
2020
medline:
15
12
2020
entrez:
19
8
2020
Statut:
ppublish
Résumé
Sepsis is defined as life-threatening organ dysfunction caused by a deregulated immune host response to infection. The emergence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has highlighted this multifactorial and complex syndrome. The absence of specific treatment neither against SARS-CoV-2 nor against acute respiratory distress syndrome (ARDS), the most serious stage of this infection, has emphasized the need to find alternative treatments. Several therapeutics are currently being tested, including mesenchymal stromal cells. These cells, already used in preclinical models of ARDS, sepsis, and septic shock and also in a few clinical trials, appear well-tolerated and promising, but many questions remain unanswered.
Identifiants
pubmed: 32808462
doi: 10.1002/sctm.20-0239
pmc: PMC7461462
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1488-1494Informations de copyright
© 2020 The Authors. STEM CELLS Translational Medicine published by Wiley Periodicals LLC on behalf of AlphaMed Press.
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