Small vessel disease more than Alzheimer's disease determines diffusion MRI alterations in memory clinic patients.
Alzheimer's disease
biomarker
cerebral small vessel disease
diffusion tensor imaging
free water imaging
white matter
Journal
Alzheimer's & dementia : the journal of the Alzheimer's Association
ISSN: 1552-5279
Titre abrégé: Alzheimers Dement
Pays: United States
ID NLM: 101231978
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
23
03
2020
revised:
25
06
2020
accepted:
25
06
2020
pubmed:
19
8
2020
medline:
28
9
2021
entrez:
19
8
2020
Statut:
ppublish
Résumé
Microstructural alterations as assessed by diffusion tensor imaging (DTI) are key findings in both Alzheimer's disease (AD) and small vessel disease (SVD). We determined the contribution of each of these conditions to diffusion alterations. We studied six samples (N = 365 participants) covering the spectrum of AD and SVD, including genetically defined samples. We calculated diffusion measures from DTI and free water imaging. Simple linear, multivariable random forest, and voxel-based regressions were used to evaluate associations between AD biomarkers (amyloid beta, tau), SVD imaging markers, and diffusion measures. SVD markers were strongly associated with diffusion measures and showed a higher contribution than AD biomarkers in multivariable analysis across all memory clinic samples. Voxel-wise analyses between tau and diffusion measures were not significant. In memory clinic patients, the effect of SVD on diffusion alterations largely exceeds the effect of AD, supporting the value of diffusion measures as markers of SVD.
Identifiants
pubmed: 32808747
doi: 10.1002/alz.12150
pmc: PMC8102202
mid: NIHMS1697447
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1504-1514Subventions
Organisme : Austrian Science Fund FWF
ID : I 2889
Pays : Austria
Organisme : NIA NIH HHS
ID : U01 AG024904
Pays : United States
Organisme : NIA NIH HHS
ID : U19 AG024904
Pays : United States
Organisme : NIA NIH HHS
ID : U19 AG032438
Pays : United States
Informations de copyright
© 2020 the Alzheimer's Association.
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