Does thiamine protect the brain from iron overload and alcohol-related dementia?
alcohol use disorder
blood-brain barrier
brain iron accumulation
cognitive decline
dementia
neurodegeneration
neurotoxicity
thiamine
Journal
Alzheimer's & dementia : the journal of the Alzheimer's Association
ISSN: 1552-5279
Titre abrégé: Alzheimers Dement
Pays: United States
ID NLM: 101231978
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
26
03
2019
revised:
02
06
2020
accepted:
17
06
2020
pubmed:
19
8
2020
medline:
28
9
2021
entrez:
19
8
2020
Statut:
ppublish
Résumé
Alcohol-related dementia (ARD) is a common and severe co-morbidity in alcohol use disorder (AUD). We propose brain iron overload (BIO) to be an important and previously neglected pathogenic process, accelerating cognitive decline in AUD. Furthermore, we suggest thiamine, which is frequently depleted in AUD, to be a key modulator in this process: Thiamine deficiency impairs the integrity of the blood-brain barrier, thereby enabling iron to pass through and accumulate in the brain. This hypothesis is based on findings from animal, translational, and neuroimaging studies, discussed in this article. To validate this hypothesis, translational studies focusing on brain iron homeostasis in AUD, as well as prospective clinical studies investigating prevalence and clinical impact of BIO in AUD, should be conducted. If proven right, this would change the understanding of ARD and may lead to novel therapeutic interventions in prevention and treatment of ARD.
Identifiants
pubmed: 32808749
doi: 10.1002/alz.12146
pmc: PMC7983902
doi:
Substances chimiques
Thiamine
X66NSO3N35
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1591-1595Informations de copyright
© 2020 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
Références
Neurochem Int. 2013 Jan;62(2):165-72
pubmed: 23262393
Ageing Res Rev. 2017 May;35:265-290
pubmed: 27829171
Adv Exp Med Biol. 2019;1173:153-177
pubmed: 31456210
Diabetes Care. 2019 May;42(5):972-979
pubmed: 30833374
Eur J Neurol. 2006 Oct;13(10):1078-82
pubmed: 16987159
Alcohol Res Health. 2003;27(2):134-42
pubmed: 15303623
Alcohol Alcohol. 1992 Sep;27(5):539-44
pubmed: 1476557
Metab Brain Dis. 1995 Jun;10(2):159-74
pubmed: 7675014
Diabetes Care. 2014 Nov;37(11):3076-83
pubmed: 25125507
Alcohol Clin Exp Res. 2001 Jul;25(7):1037-45
pubmed: 11505030
Front Neurosci. 2018 Sep 10;12:632
pubmed: 30250423
J Neuropathol Exp Neurol. 1999 Sep;58(9):946-58
pubmed: 10499437
Liver Int. 2007 Dec;27(10):1394-401
pubmed: 17927713
Handb Clin Neurol. 2018;147:293-305
pubmed: 29325618
Brain Res Bull. 2020 Mar;156:1-9
pubmed: 31866454
Lancet. 2013 Nov 9;382(9904):1575-86
pubmed: 23993280
Lancet. 2002 Jan 26;359(9303):281-6
pubmed: 11830193
Alcohol Clin Exp Res. 1992 Apr;16(2):320-5
pubmed: 1317136
Neuroscience. 2005;135(4):1129-39
pubmed: 16165302
Neuroimage. 2017 Mar 1;148:115-122
pubmed: 28065850
Ann Emerg Med. 2007 Dec;50(6):715-21
pubmed: 17681641
Int J Vitam Nutr Res. 2001 Jul;71(4):217-21
pubmed: 11582856
Glia. 2012 May;60(6):948-64
pubmed: 22431236
Nature. 2019 Nov;575(7784):693-698
pubmed: 31634899
Mol Neurobiol. 2017 Sep;54(7):5440-5448
pubmed: 27596507
J Neurol. 2007 Sep;254(9):1296-7
pubmed: 17450315
Br J Psychiatry. 2008 Nov;193(5):351-3
pubmed: 18978310
World J Gastroenterol. 2019 Feb 7;25(5):521-538
pubmed: 30774269
J Nutr. 2007 Dec;137(12):2809-13
pubmed: 18029504
J Struct Biol. 2006 Jul;155(1):45-51
pubmed: 16503166
Molecules. 2019 Apr 07;24(7):
pubmed: 30959950
Am J Gastroenterol. 2019 Dec;114(12):1927
pubmed: 31724994
N Engl J Med. 2013 Aug 8;369(6):540-8
pubmed: 23924004
J Neurol Sci. 1998 Jun 11;158(1):47-52
pubmed: 9667777
Adv Nutr. 2015 Mar 13;6(2):147-53
pubmed: 25770253
Int J Environ Res Public Health. 2009 Jul;6(7):2055-75
pubmed: 19742171
Neuroscience. 2014 Sep 26;277:139-51
pubmed: 24998895
J Neurosci. 2015 Apr 29;35(17):6731-43
pubmed: 25926451
J Alzheimers Dis. 2013;33 Suppl 1:S277-81
pubmed: 22635102
Oxid Med Cell Longev. 2013;2013:726954
pubmed: 23710288
Gastroenterol Hepatol (N Y). 2016 Nov;12(11):695-698
pubmed: 28035198
Cochrane Database Syst Rev. 2013 Jul 01;(7):CD004033
pubmed: 23818100
Cancer Lett. 2009 Dec 1;286(1):38-43
pubmed: 19081672
Lancet. 2018 Sep 22;392(10152):1015-1035
pubmed: 30146330
Alcohol Alcohol. 2009 Mar-Apr;44(2):136-40
pubmed: 19147798
Alzheimers Dement. 2020 Nov;16(11):1591-1595
pubmed: 32808749
Redox Biol. 2018 Apr;14:535-548
pubmed: 29126071
J Neurochem. 1958 Oct;3(1):41-51
pubmed: 13611557
Neurobiol Aging. 2013 Feb;34(2):562-75
pubmed: 22717236
J Intern Med. 1994 Sep;236(3):315-22
pubmed: 8077889
Hepatology. 2012 Jan;55(1):77-85
pubmed: 21953442
Eur J Epidemiol. 2015 Sep;30(9):1049-56
pubmed: 25968174
Alcohol Clin Exp Res. 1992 Dec;16(6):1078-89
pubmed: 1471762