Conservative oxygen therapy for mechanically ventilated adults with suspected hypoxic ischaemic encephalopathy.
Cardiac arrest
Critical care
Hypoxic ischemic encephalopathy
Intensive care medicine
Oxygen therapy
Randomized controlled trial
Journal
Intensive care medicine
ISSN: 1432-1238
Titre abrégé: Intensive Care Med
Pays: United States
ID NLM: 7704851
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
31
05
2020
accepted:
20
07
2020
pubmed:
19
8
2020
medline:
22
5
2021
entrez:
19
8
2020
Statut:
ppublish
Résumé
Liberal use of oxygen may contribute to secondary brain injury in patients with hypoxic-ischaemic encephalopathy (HIE). However, there are limited data on the effect of different oxygen regimens on survival and neurological disability in HIE patients. We undertook a post-hoc analysis of the 166 patients with suspected HIE enrolled in a trial comparing conservative oxygen therapy with usual oxygen therapy in 1000 mechanically ventilated ICU patients. The primary endpoint for the current analysis was death or unfavourable neurological outcome at day 180. Key secondary outcomes were day 180 mortality, and cause-specific mortality. Patients with HIE allocated to conservative oxygen spent less time in the ICU with an SpO Conservative oxygen therapy was not associated with a statistically significant reduction in death or unfavourable neurological outcomes at day 180. The potential for important benefit or harm from conservative oxygen therapy in HIE patients is not excluded by these data.
Identifiants
pubmed: 32809136
doi: 10.1007/s00134-020-06196-y
pii: 10.1007/s00134-020-06196-y
pmc: PMC7431900
doi:
Substances chimiques
Oxygen
S88TT14065
Types de publication
Clinical Trial
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2411-2422Investigateurs
Tanya Baker
(T)
Sally Hurford
(S)
Mary La Pine
(M)
Diane Mackle
(D)
Carla McInnes
(C)
Leanlove Navarra
(L)
Allison Pritchard
(A)
Raulle Sol Cruz
(RS)
Anne Turner
(A)
Tessa Broadley
(T)
Victoria King
(V)
Dana Lee
(D)
Natalie Linke
(N)
Liadain Reid
(L)
Lynnette Murray
(L)
Aimee Blakemore
(A)
Magdalena Butler
(M)
Keri-Anne Cowdrey
(KA)
Eileen Gilder
(E)
Jane Hallion
(J)
Stephanie Long
(S)
Shay McGuinness
(S)
Philippa Neal
(P)
Rachael Parke
(R)
Samantha Wallace
(S)
Yan Chen
(Y)
Colin McArthur
(C)
Rachael McConnochie
(R)
Lynette Newby
(L)
Catherine Simmonds
(C)
David Bowie
(D)
Brandon Burke
(B)
David Closey
(D)
Rosalind Crombie
(R)
Neil Davidson
(N)
Andrew Greer
(A)
Seton Henderson
(S)
Louise Hitchings
(L)
David Knight
(D)
Jan Mehrtens
(J)
Kate Miller
(K)
Emmeline Minto
(E)
Stacey Morgan
(S)
Anna Morris
(A)
Kim Parker
(K)
Jay Ritzema-Carter
(J)
Jessica Roberts
(J)
Christian Sahl
(C)
Geoffrey Shaw
(G)
Katherine Townend
(K)
Llesley Chadwick
(L)
Debra Chalmers
(D)
Ross Freebairn
(R)
Michael Park
(M)
Penelope Park
(P)
Christine Rolls
(C)
Carmel Chapman
(C)
Andrew Stapleton
(A)
Jefferson Aguila
(J)
Anisha Dias
(A)
Alex Kazemi
(A)
Vivian Lai
(V)
Rima Song
(R)
Tony Williams
(T)
Sheila Caniba
(S)
Maud Carpenter
(M)
Rica Dagooc
(R)
Danielle Hacking
(D)
Ywain Lawrey
(Y)
Ulrike Buehner
(U)
Erin Williams
(E)
Jonathan Albrett
(J)
Carolyn Jackson
(C)
Peter Marko
(P)
Ben Barry
(B)
Nina Beehre
(N)
Dick Dinsdale
(D)
Samantha Edney
(S)
Frances Fitzjohn
(F)
Peter Hicks
(P)
Georgia Hill
(G)
Anna Hunt
(A)
Harriet Judd
(H)
Charlotte Latimer-Bell
(C)
Cassie Lawrence
(C)
Eden Lesona
(E)
Agnes McKay-Vucago
(A)
Leanlove Navarra
(L)
Chris Poynter
(C)
Alex Psirides
(A)
Yvonne Robertson
(Y)
Hannah Smellie
(H)
Raulle Sol Cruz
(RS)
Shawn Sturland
(S)
Bob Ure
(B)
Paul Young
(P)
Jasmin Board
(J)
Aidan Burrell
(A)
Tim Byrne
(T)
Eliza Dean
(E)
Emma Martin
(E)
Chris Mason
(C)
Phoebe McCracken
(P)
Sacha Richardson
(S)
Shirley Vallance
(S)
Meredith Young
(M)
Rinaldo Bellomo
(R)
Glenn Eastwood
(G)
Leah Peck
(L)
Helen Young
(H)
Ege Eroglu
(E)
Edward Litton Ame
(E)
Annemarie Palermo
(A)
Susan Pellicano
(S)
Shailesh Bihari
(S)
Xia Jin
(X)
Russell Laver
(R)
Elisha Matheson
(E)
Kate Schwartz
(K)
Tapaswi Shrestha
(T)
Timothy Beckingham
(T)
Natalie Soar
(N)
Dhiraj Bhatia
(D)
Lauren Bulfin
(L)
Timothy Crozier
(T)
Klaudija Lavrans
(K)
Julie Luong
(J)
Venkata Maduri
(V)
Michael Patterson
(M)
Chloe Peppin
(C)
Angela Wang
(A)
Catherine Kurenda
(C)
Sandra Peake
(S)
Nadeem Robaa
(N)
Patricia Williams
(P)
Lukasz Badek
(L)
Stanley Bart
(S)
Marianne Chapman
(M)
Michael Davies
(M)
Adam Deane
(A)
Sarah Doherty
(S)
Kathleen Glasby
(K)
Samuel Gluck
(S)
Robert Grieve
(R)
Palesh Karr
(P)
Joanne McIntyre
(J)
Stephanie O'Connor
(S)
Alexis Poole
(A)
Eamon Raith
(E)
Benjamin Reddi
(B)
Justine Rivett
(J)
Sandeep Sethi
(S)
Joannies Yap
(J)
Nikki Yeo
(N)
Yasmine Aliabdelhamind
(Y)
James Anstey
(J)
Deborah Barge
(D)
Kathleen Byrne
(K)
Adam Deane
(A)
Sarah Doherty
(S)
Paul Emery
(P)
Peter Forrest
(P)
Madeline Haile
(M)
Sandra Lussier
(S)
Tom Rechnitzer
(T)
Geoffrey Wigmore
(G)
Annemarie Palermo
(A)
Susan Pellicano
(S)
Adrian Regli
(A)
Leanne Barbazza
(L)
Barry Dixon
(B)
Jennifer Holmes
(J)
John Santamaria
(J)
Roger Smith
(R)
Antony Tobin
(A)
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