The PRIAMO study: age- and sex-related relationship between prodromal constipation and disease phenotype in early Parkinson's disease.

Aged Apathy Biomarkers Constipation / epidemiology Female Humans Male Parkinson Disease / complications Phenotype Prodromal Symptoms
Constipation Heterogeneity Parkinson Phenotype Prodromal Sex

Journal

Journal of neurology
ISSN: 1432-1459
Titre abrégé: J Neurol
Pays: Germany
ID NLM: 0423161

Informations de publication

Date de publication:
Feb 2021
Historique:
received: 12 05 2020
accepted: 10 08 2020
revised: 21 07 2020
pubmed: 19 8 2020
medline: 22 6 2021
entrez: 19 8 2020
Statut: ppublish

Résumé

To explore the impact of sex and age on relationship between prodromal constipation and disease phenotype in Parkinson's disease at early stages. A total of 385 Parkinson's disease patients from the PRIAMO study were classified according to the presence of prodromal constipation and followed for 24 months. Multivariable mixed-effect models were applied. All analyses were performed separately for sex (64.1% men) and median age (different by sex: 67 years-old in men and 68 years-old in women). As for sex, prodromal constipation was associated with greater odds of attention/memory complaints and apathy symptoms in women only. As for age, prodromal constipation was associated with lower cognitive and higher apathy scores in older patients only. Prodromal constipation anticipates lower cognitive performances and more severe apathy since the earliest stages in women and older patients. Sex- and age-related heterogeneity of prodromal markers of Parkinson's disease may impact disease phenotype.

Identifiants

DOI: 10.1007/s00415-020-10156-3 PMID: 32809151 PMC: PMC7880965
pubmed: 32809151
doi: 10.1007/s00415-020-10156-3
pii: 10.1007/s00415-020-10156-3
pmc: PMC7880965
doi:

Substances chimiques

Biomarkers 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

448-454

Investigateurs

Angelo Antonini (A)
Carlo Colosimo (C)
Roberto Marconi (R)
Letterio Morgante (L)
D Benincasa (D)
R Quatrale (R)
S Biguzzi (S)
M Braga (M)
G Ceravolo (G)
M Capecci (M)
G Meco (G)
N Caravona (N)
R Scala (R)
F A De Falco (FA)
G Pezzoli (G)
D De Gaspari (D)
E Bottacchi (E)
M Di Giovanni (M)
A Cannas (A)
G Floris (G)
S Gallerini (S)
L Grasso (L)
R M Gaglio (RM)
G Gurgone (G)
G Volpe (G)
S Zappulla (S)
R Ceravolo (R)
L Kiferle (L)
S Ramat (S)
S Meoni (S)
A Pisani (A)
V Moschella (V)
F Morgante (F)
R Savica (R)
F Pepe (F)
G Ciccarelli (G)
V Petretta (V)
R M Giglia (RM)
M G Randisi (MG)
F Iemolo (F)
T P Avarello (TP)
M Romeno (M)
G Santangelo (G)
F Stocchi (F)
G Sciortino (G)
V Sorbello (V)
A Nicoletti (A)
D Tiple (D)
G Fabbrini (G)
A Bentivoglio (A)
F E Pontieri (FE)
A Guidubaldi (A)
R Muoio (R)
V Toni (V)
P Del Dotto (P)
C Logi (C)
G Ciacci (G)
M Ulivelli (M)
M Perini (M)
S Lanfranchi (S)
S Griffini (S)
B Troianiello (B)
M Baratti (M)
S Amidei (S)
D Consoli (D)
M Iellamo (M)
T Cuomo (T)
A Scaglioni (A)
D Medici (D)
M Manfredi (M)
G Abbruzzese (G)
G Di Brigida (G)
G A Cocco (GA)
V Agnetti (V)
G Cossu (G)
M Deriu (M)
M Abrignani (M)
C Modica (C)
G Albani (G)
E Milan (E)
P Martinelli (P)
C Scaglione (C)
M Mucchiut (M)
S Zanini (S)
F Pennisi (F)
P Soliveri (P)
A Albanese (A)
Pederzoli Massimo (P)
L Bartolomei (L)
L Capus (L)
L Ferigo (L)
R Marano (R)
V Nastasi (V)
R Luciano (R)
L Maiello (L)
P Simone (P)
D Fogli (D)
L Lopiano (L)
M Pesare (M)
G Nordera (G)
E Pilleri (E)
T Scaravilli (T)
E Giaccaglini (E)
C Alesi (C)
A Petrone (A)
G Trianni (G)

Références

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Auteurs

Marina Picillo (M)

Department of Medicine, Surgery and Dentistry, Neuroscience Section, Center for Neurodegenerative Diseases (CEMAND), University of Salerno, Salerno, 84131, Italy.
ORCID: 0000-0001-9025-137X

Raffaele Palladino (R)

Department of Primary Care and Public Health, School of Public Health, Imperial College of London, London, UK.
Department of Public Health, School of Medicine, University "Federico II", Naples, Italy.

Roberto Erro (R)

Department of Medicine, Surgery and Dentistry, Neuroscience Section, Center for Neurodegenerative Diseases (CEMAND), University of Salerno, Salerno, 84131, Italy.

Rossella Alfano (R)

Department of Public Health, School of Medicine, University "Federico II", Naples, Italy.

Carlo Colosimo (C)

Department of Neurology, Santa Maria University Hospital, Terni, Italy.

Roberto Marconi (R)

Neurology Division, Misericordia Hospital, Grosseto, Italy.

Angelo Antonini (A)

Department of Neurosciences (DNS), Padova University, Padua, Italy.

Paolo Barone (P)

Department of Medicine, Surgery and Dentistry, Neuroscience Section, Center for Neurodegenerative Diseases (CEMAND), University of Salerno, Salerno, 84131, Italy. pbarone@unisa.it.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › The PRIAMO study: age- and sex-related...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Émotions › Apathie › The PRIAMO study: age- and sex-related...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › The PRIAMO study: age- and sex-related...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Signes et symptômes digestifs › Constipation › The PRIAMO study: age- and sex-related...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The PRIAMO study: age- and sex-related...
questionsmedicales.fr › Maladies du système nerveux › Maladies neurodégénératives › Maladie de Parkinson › The PRIAMO study: age- and sex-related...
questionsmedicales.fr › Phénomènes génétiques › Phénotype › The PRIAMO study: age- and sex-related...
questionsmedicales.fr › Diagnostic › Symptômes prodromiques › The PRIAMO study: age- and sex-related...