Non-invasively measured central and peripheral factors of oxygen uptake differ between patients with chronic heart failure and healthy controls.
Activities of Daily Living
Aged
Case-Control Studies
Chronic Disease
Cross-Sectional Studies
Exercise Test
Heart Failure
/ diagnosis
Hemodynamics
Humans
Isometric Contraction
Male
Middle Aged
Muscle Strength
Oxygen Consumption
Predictive Value of Tests
Quadriceps Muscle
/ metabolism
Spectroscopy, Near-Infrared
Activities of daily life
Alternative statistics
Arteriovenous oxygen difference
Clinical practice
Lactate
Questionnaire
Variability
Journal
BMC cardiovascular disorders
ISSN: 1471-2261
Titre abrégé: BMC Cardiovasc Disord
Pays: England
ID NLM: 100968539
Informations de publication
Date de publication:
18 08 2020
18 08 2020
Historique:
received:
06
05
2020
accepted:
09
08
2020
entrez:
20
8
2020
pubmed:
20
8
2020
medline:
12
1
2021
Statut:
epublish
Résumé
Maximum oxygen uptake is an established measurement of diagnosing chronic heart failure and underlies various central and peripheral factors. However, central and peripheral factors are little investigated, because they are usually measured invasively. The aim of this study was to compare non-invasively measured central and peripheral factors of oxygen uptake between patients with chronic heart failure and healthy controls. Ten male patients with heart failure with reduced ejection fraction (62 ± 4 years; body mass index: 27.7 ± 1.8 kg/m Patients had a likely to most likely lower oxygen uptake, mean arterial pressure, and heart rate at maximum load as well as very likely lower isometric peak torque. Contrary, patients had a possibly to likely higher stroke volume and muscle oxygen saturation of the vastus lateralis muscle at maximum load. Differences in cardiac output, cardiac power output, and muscle oxygen saturation of the biceps brachii muscle at maximum load were unclear. Non-invasively measured central and peripheral factors of oxygen uptake differ between patients with chronic heart failure and healthy controls. Therefore, it is promising to measure both types of factors in patients with chronic heart failure to optimize the diagnosis and therapy.
Sections du résumé
BACKGROUND
Maximum oxygen uptake is an established measurement of diagnosing chronic heart failure and underlies various central and peripheral factors. However, central and peripheral factors are little investigated, because they are usually measured invasively. The aim of this study was to compare non-invasively measured central and peripheral factors of oxygen uptake between patients with chronic heart failure and healthy controls.
METHODS
Ten male patients with heart failure with reduced ejection fraction (62 ± 4 years; body mass index: 27.7 ± 1.8 kg/m
RESULTS
Patients had a likely to most likely lower oxygen uptake, mean arterial pressure, and heart rate at maximum load as well as very likely lower isometric peak torque. Contrary, patients had a possibly to likely higher stroke volume and muscle oxygen saturation of the vastus lateralis muscle at maximum load. Differences in cardiac output, cardiac power output, and muscle oxygen saturation of the biceps brachii muscle at maximum load were unclear.
CONCLUSIONS
Non-invasively measured central and peripheral factors of oxygen uptake differ between patients with chronic heart failure and healthy controls. Therefore, it is promising to measure both types of factors in patients with chronic heart failure to optimize the diagnosis and therapy.
Identifiants
pubmed: 32811426
doi: 10.1186/s12872-020-01661-4
pii: 10.1186/s12872-020-01661-4
pmc: PMC7437074
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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