Quantitative bone marrow magnetic resonance imaging through apparent diffusion coefficient and fat fraction in multiple myeloma patients.
Adipose Tissue
/ diagnostic imaging
Adult
Aged
Aged, 80 and over
Analysis of Variance
Body Water
/ diagnostic imaging
Bone Marrow
/ diagnostic imaging
Case-Control Studies
Diffusion Magnetic Resonance Imaging
/ methods
Disease Progression
Female
Humans
Male
Middle Aged
Multiple Myeloma
/ diagnostic imaging
Retrospective Studies
Sensitivity and Specificity
Spine
/ diagnostic imaging
ADC
Chemical shift imaging
DWI
Fat fraction
Multiple myeloma
Whole body MRI
Journal
La Radiologia medica
ISSN: 1826-6983
Titre abrégé: Radiol Med
Pays: Italy
ID NLM: 0177625
Informations de publication
Date de publication:
Mar 2021
Mar 2021
Historique:
received:
13
11
2019
accepted:
10
08
2020
pubmed:
20
8
2020
medline:
20
3
2021
entrez:
20
8
2020
Statut:
ppublish
Résumé
Quantitative bone marrow (BM) MR sequences, as DWI and CSI, were used to evaluate BM water-fat composition. The aim of the study was to assess the potential usefulness of fat fraction (FF) and ADC, calculated by CSI or DWI, in diagnosing and classifying myeloma (MM) patients according to their different BM infiltration patterns. The study group included 43 MM patients (19F; 24M; mean age 64 years), 15 asymptomatic, 15 symptomatic with diffuse BM infiltration and 13 symptomatic with focal lesions (FLs). The control group was made up of 15 healthy subjects (7F; 8M; mean age 64 years). MRI examinations consisted of sagittal T1w TSE on the spinal column, axial DWI (b 50-400-800 mm ANOVA with Bonferroni's correction showed a significant difference in ADC values among the different groups of MM patients (P < 0.05), while FF was only significantly different between patients with diffuse infiltration and patients with FL (P = 0.002). ADC allowed distinguishing MM patients from normal BM patients with diffuse BM infiltration (cutoff value: 0.491 × 10 ADC and FF are potentially useful parameter for the quantitative evaluation of BM infiltration in MM patients.
Identifiants
pubmed: 32812173
doi: 10.1007/s11547-020-01258-z
pii: 10.1007/s11547-020-01258-z
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
445-452Références
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