Changes in the intracellular microenvironment in the aging human brain.

Adolescent Adult Aged Aged, 80 and over Aging / metabolism Aspartic Acid / metabolism Brain / cytology Brain Chemistry Cellular Microenvironment / physiology Choline / metabolism Creatine / metabolism Female Glutamic Acid / metabolism Humans Inositol / metabolism Magnetic Resonance Spectroscopy Male Young Adult
ADC Diffusion Magnetic resonance spectroscopy T(2) Young

Journal

Neurobiology of aging
ISSN: 1558-1497
Titre abrégé: Neurobiol Aging
Pays: United States
ID NLM: 8100437

Informations de publication

Date de publication:
11 2020
Historique:
received: 09 04 2020
revised: 23 06 2020
accepted: 19 07 2020
pubmed: 20 8 2020
medline: 10 7 2021
entrez: 20 8 2020
Statut: ppublish

Résumé

Normal brain aging is associated with changes occurring at all levels. This study investigates age-related differences in the brain intracellular microenvironment by comparing the apparent diffusion coefficients (ADC) and apparent transverse relaxation time constants (T

Identifiants

DOI: 10.1016/j.neurobiolaging.2020.07.017 PMID: 32814258 PMC: PMC7609490
pubmed: 32814258
pii: S0197-4580(20)30233-5
doi: 10.1016/j.neurobiolaging.2020.07.017
pmc: PMC7609490
mid: NIHMS1616410
pii:
doi:

Substances chimiques

Aspartic Acid 30KYC7MIAI
Glutamic Acid 3KX376GY7L
Inositol 4L6452S749
Creatine MU72812GK0
Choline N91BDP6H0X

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

168-175

Subventions

Organisme : NINDS NIH HHS
ID : P30 NS076408
Pays : United States
Organisme : NIBIB NIH HHS
ID : P41 EB015894
Pays : United States
Organisme : NIBIB NIH HHS
ID : P41 EB027061
Pays : United States
Organisme : NIA NIH HHS
ID : R21 AG045606
Pays : United States

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

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Auteurs

Dinesh K Deelchand (DK)

Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN, USA. Electronic address: deelc001@umn.edu.

J Riley McCarten (JR)

Geriatric Research, Education and Clinical Center, Veterans Affairs Health Care System, Minneapolis, MN, USA; Department of Neurology, University of Minnesota, Minneapolis, MN, USA.

Laura S Hemmy (LS)

Geriatric Research, Education and Clinical Center, Veterans Affairs Health Care System, Minneapolis, MN, USA; Department of Psychiatry, University of Minnesota, Minneapolis, MN, USA.

Edward J Auerbach (EJ)

Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN, USA.

Lynn E Eberly (LE)

Division of Biostatistics, University of Minnesota, Minneapolis, MN, USA.

Małgorzata Marjańska (M)

Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN, USA.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adolescent › Changes in the intracellular microenvironment...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Changes in the intracellular microenvironment...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Changes in the intracellular microenvironment...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Sujet âgé de 80 ans ou plus › Changes in the intracellular microenvironment...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › Changes in the intracellular microenvironment...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés excitateurs › Acide aspartique › Changes in the intracellular microenvironment...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Changes in the intracellular microenvironment...
questionsmedicales.fr › Métabolisme › Chimie du cerveau › Changes in the intracellular microenvironment...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Microenvironnement cellulaire › Changes in the intracellular microenvironment...
questionsmedicales.fr › Composés chimiques organiques › Composés onium › Composés d'ammonium quaternaire › Choline › Changes in the intracellular microenvironment...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Créatine › Changes in the intracellular microenvironment...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés excitateurs › Acide glutamique › Changes in the intracellular microenvironment...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Changes in the intracellular microenvironment...
questionsmedicales.fr › Glucides › Polyols › Inositol › Changes in the intracellular microenvironment...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Analyse spectrale › Spectroscopie par résonance magnétique › Changes in the intracellular microenvironment...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Jeune adulte › Changes in the intracellular microenvironment...