Lymph protects metastasizing melanoma cells from ferroptosis.
Animals
Cell Survival
Coenzyme A Ligases
/ metabolism
Female
Ferroptosis
/ drug effects
Glutathione
/ metabolism
Humans
Iron
/ metabolism
Lymph
/ metabolism
Male
Melanoma
/ blood
Mice
Neoplasm Metastasis
/ drug therapy
Oleic Acid
/ metabolism
Oxidative Stress
/ drug effects
Phospholipid Hydroperoxide Glutathione Peroxidase
/ metabolism
Principal Component Analysis
Journal
Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
received:
19
11
2019
accepted:
08
07
2020
pubmed:
21
8
2020
medline:
6
10
2020
entrez:
21
8
2020
Statut:
ppublish
Résumé
Cancer cells, including melanoma cells, often metastasize regionally through the lymphatic system before metastasizing systemically through the blood
Identifiants
pubmed: 32814895
doi: 10.1038/s41586-020-2623-z
pii: 10.1038/s41586-020-2623-z
pmc: PMC7484468
mid: NIHMS1610560
doi:
Substances chimiques
Oleic Acid
2UMI9U37CP
Iron
E1UOL152H7
Phospholipid Hydroperoxide Glutathione Peroxidase
EC 1.11.1.12
glutathione peroxidase 4, mouse
EC 1.11.1.9
Acsl3 protein, mouse
EC 6.1.2.3
Coenzyme A Ligases
EC 6.2.1.-
Glutathione
GAN16C9B8O
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
113-118Subventions
Organisme : NCI NIH HHS
ID : P30 CA086862
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA228608
Pays : United States
Organisme : NHLBI NIH HHS
ID : F32 HL139016
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA217797
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES005605
Pays : United States
Commentaires et corrections
Type : CommentIn
Type : CommentIn
Type : CommentIn
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