Developmental Changes in Dendritic Spine Morphology in the Striatum and Their Alteration in an A53T α-Synuclein Transgenic Mouse Model of Parkinson's Disease.
A53T
FIB/SEM
Parkinson’s disease
dendrite
dendritic spines
α-synuclein
Journal
eNeuro
ISSN: 2373-2822
Titre abrégé: eNeuro
Pays: United States
ID NLM: 101647362
Informations de publication
Date de publication:
Historique:
received:
27
02
2020
revised:
12
08
2020
accepted:
12
08
2020
pubmed:
21
8
2020
medline:
22
6
2021
entrez:
21
8
2020
Statut:
epublish
Résumé
The aging process is accompanied by various neurophysiological changes, and the severity of neurodegenerative disorders such as Parkinson's disease (PD) increases with aging. However, the precise neuroanatomical changes that accompany the aging process in both normal and pathologic conditions remain unknown. This is in part because there is a lack of high-resolution imaging tool that has the capacity to image a desired volume of neurons in a high-throughput and automated manner. In the present study, focused ion beam/scanning electron microscopy (FIB/SEM) was used to image striatal neuropil in both wild-type (WT) mice and an A53T bacterial artificial chromosome (BAC) human α-synuclein (A53T-BAC-
Identifiants
pubmed: 32817196
pii: ENEURO.0072-20.2020
doi: 10.1523/ENEURO.0072-20.2020
pmc: PMC7470930
pii:
doi:
Substances chimiques
Snca protein, mouse
0
alpha-Synuclein
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2020 Parajuli et al.
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