Pathophysiological regulation of lung function by the free fatty acid receptor FFA4.

Animals Fatty Acids, Nonesterified Lung Mice Pyroglyphidae Receptors, G-Protein-Coupled Signal Transduction

Journal

Science translational medicine
ISSN: 1946-6242
Titre abrégé: Sci Transl Med
Pays: United States
ID NLM: 101505086

Informations de publication

Date de publication:
19 08 2020
Historique:
received: 06 02 2019
revised: 22 10 2019
accepted: 28 07 2020
entrez: 21 8 2020
pubmed: 21 8 2020
medline: 24 6 2021
Statut: ppublish

Résumé

Increased prevalence of inflammatory airway diseases including asthma and chronic obstructive pulmonary disease (COPD) together with inadequate disease control by current frontline treatments means that there is a need to define therapeutic targets for these conditions. Here, we investigate a member of the G protein-coupled receptor family, FFA4, that responds to free circulating fatty acids including dietary omega-3 fatty acids found in fish oils. We show that FFA4, although usually associated with metabolic responses linked with food intake, is expressed in the lung where it is coupled to G

Identifiants

DOI: 10.1126/scitranslmed.aaw9009 PMID: 32817367
pubmed: 32817367
pii: 12/557/eaaw9009
doi: 10.1126/scitranslmed.aaw9009
pii:
doi:

Substances chimiques

Fatty Acids, Nonesterified 0
Receptors, G-Protein-Coupled 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/K019864/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/R00305X/1
Pays : United Kingdom

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

Auteurs

Rudi Prihandoko (R)

Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow Glasgow, G12 8QQ, Scotland, UK.
ORCID: 0000-0002-3941-1451

Davinder Kaur (D)

Institute for Lung Health, Leicester NIHR Biomedical Research Centre, University of Leicester, LE3 9QP, Leicester, UK.
ORCID: 0000-0002-8875-0660

Coen H Wiegman (CH)

Airway Disease Section, National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK.
ORCID: 0000-0001-9161-0581

Elisa Alvarez-Curto (E)

Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow Glasgow, G12 8QQ, Scotland, UK.
ORCID: 0000-0003-4004-4545

Chantal Donovan (C)

Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute, New Lambton, NSW 2305 and The University of Newcastle, Callaghan, NSW 2208, Australia.
Centre for Inflammation, Centenary Institute, Sydney, NSW 2050, and University of Technology Sydney, Faculty of Science, Ultimo NSW 2007, Australia.

Latifa Chachi (L)

Institute for Lung Health, Leicester NIHR Biomedical Research Centre, University of Leicester, LE3 9QP, Leicester, UK.
ORCID: 0000-0002-9142-4700

Trond Ulven (T)

Department of Drug Design and Pharmacology, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.
ORCID: 0000-0002-8135-1755

Martha R Tyas (MR)

Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow Glasgow, G12 8QQ, Scotland, UK.

Eloise Euston (E)

Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow Glasgow, G12 8QQ, Scotland, UK.
ORCID: 0000-0002-9937-1375

Zhaoyang Dong (Z)

Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow Glasgow, G12 8QQ, Scotland, UK.
ORCID: 0000-0002-1929-1026

Abdulrahman Ghali M Alharbi (AGM)

Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow Glasgow, G12 8QQ, Scotland, UK.
Department of Pharmacology and Toxicology, College of Pharmacy, Taibah University, Madinah 42353, Saudi Arabia.

Richard Y Kim (RY)

Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute, New Lambton, NSW 2305 and The University of Newcastle, Callaghan, NSW 2208, Australia.
Centre for Inflammation, Centenary Institute, Sydney, NSW 2050, and University of Technology Sydney, Faculty of Science, Ultimo NSW 2007, Australia.

Jack G Lowe (JG)

Airway Disease Section, National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK.
ORCID: 0000-0002-1535-2418

Philip M Hansbro (PM)

Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute, New Lambton, NSW 2305 and The University of Newcastle, Callaghan, NSW 2208, Australia.
Centre for Inflammation, Centenary Institute, Sydney, NSW 2050, and University of Technology Sydney, Faculty of Science, Ultimo NSW 2007, Australia.

Kian Fan Chung (KF)

Airway Disease Section, National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK.
ORCID: 0000-0001-7101-1426

Christopher E Brightling (CE)

Institute for Lung Health, Leicester NIHR Biomedical Research Centre, University of Leicester, LE3 9QP, Leicester, UK. andrew.tobin@glasgow.ac.uk graeme.milligan@glasgow.ac.uk ceb17@le.ac.uk.
ORCID: 0000-0002-9345-4903

Graeme Milligan (G)

Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow Glasgow, G12 8QQ, Scotland, UK. andrew.tobin@glasgow.ac.uk graeme.milligan@glasgow.ac.uk ceb17@le.ac.uk.
ORCID: 0000-0002-6946-3519

Andrew B Tobin (AB)

Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow Glasgow, G12 8QQ, Scotland, UK. andrew.tobin@glasgow.ac.uk graeme.milligan@glasgow.ac.uk ceb17@le.ac.uk.
ORCID: 0000-0002-1807-3123

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Classifications MeSH

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questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Pathophysiological regulation of lung function...
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Arthropodes › Arachnida › Acari › Mites (acariens) › Pyroglyphidae › Pathophysiological regulation of lung function...
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questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Pathophysiological regulation of lung function...