IL-12 p40 monomer is different from other IL-12 family members to selectively inhibit IL-12Rβ1 internalization and suppress EAE.
Adult
Animals
Cells, Cultured
Disease Models, Animal
Encephalomyelitis, Autoimmune, Experimental
/ drug therapy
Female
Humans
Interleukin-12
/ immunology
Interleukin-12 Subunit p40
/ immunology
Interleukin-23
/ immunology
Male
Mice
Mice, Inbred C57BL
Multiple Sclerosis
/ blood
Protein Binding
Receptors, Interleukin-12
/ antagonists & inhibitors
Recombinant Proteins
/ pharmacology
Signal Transduction
Th17 Cells
/ drug effects
EAE
IL-12 p40 monomer
IL-12Rβ1
multiple sclerosis
rheumatoid arthritis
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
01 09 2020
01 09 2020
Historique:
pubmed:
21
8
2020
medline:
18
11
2020
entrez:
21
8
2020
Statut:
ppublish
Résumé
Multiple sclerosis (MS) is the most common human demyelinating disease of the central nervous system. The IL-12 family of cytokines has four members, which are IL-12 (p40:p35), IL-23 (p40:p19), the p40 monomer (p40), and the p40 homodimer (p40
Identifiants
pubmed: 32817415
pii: 2000653117
doi: 10.1073/pnas.2000653117
pmc: PMC7474649
doi:
Substances chimiques
Interleukin-12 Subunit p40
0
Interleukin-23
0
Receptors, Interleukin-12
0
Recombinant Proteins
0
Interleukin-12
187348-17-0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
21557-21567Subventions
Organisme : NINDS NIH HHS
ID : R21 NS097426
Pays : United States
Organisme : BLRD VA
ID : I01 BX002174
Pays : United States
Organisme : BLRD VA
ID : IK6 BX004982
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG050431
Pays : United States
Organisme : NCCIH NIH HHS
ID : R01 AT006681
Pays : United States
Déclaration de conflit d'intérêts
The authors declare no competing interest.
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