The 14-3-3 protein is an essential component of cyclic AMP signaling for regulation of chemotaxis and development in Dictyostelium.

14-3-3 Proteins / metabolism Chemotaxis Cyclic AMP / metabolism Dictyostelium / growth & development Protozoan Proteins / metabolism
14-3-3 protein Chemotaxis Development Dictyostelium Interactome Phosphorylation cAMP signaling

Journal

Cellular signalling
ISSN: 1873-3913
Titre abrégé: Cell Signal
Pays: England
ID NLM: 8904683

Informations de publication

Date de publication:
11 2020
Historique:
received: 11 03 2020
revised: 13 08 2020
accepted: 13 08 2020
pubmed: 21 8 2020
medline: 21 10 2021
entrez: 21 8 2020
Statut: ppublish

Résumé

The evolutionarily-conserved 14-3-3 proteins regulate many cellular processes through binding to various phosphorylated targets in eukaryotes. It first appears in Dictyostelium, however its role in this organism is poorly understood. Here we show that down-regulation of the 14-3-3 impairs chemotaxis and causes multiple-tip formation in Dictyostelium. Mechanistically, the 14-3-3 is a critical component of cyclic AMP (cAMP) signaling and binds to nearly a hundred of proteins in Dictyostelium, including a number of evolutionarily-conserved proteins. 14-3-3 - interaction with its targets is up-regulated in response to developmental cues/regulators including starvation, osmotic stress and cAMP. cAMP stimulates 14-3-3 - binding to phospho-Ser431 on a guanine nucleotide exchange factor Gef-Q. Interestingly, overexpression of Gef-Q

Identifiants

DOI: 10.1016/j.cellsig.2020.109739 PMID: 32818671
pubmed: 32818671
pii: S0898-6568(20)30216-3
doi: 10.1016/j.cellsig.2020.109739
pii:
doi:

Substances chimiques

14-3-3 Proteins 0
Protozoan Proteins 0
Cyclic AMP E0399OZS9N

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

109739

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare no competing financial interests.

Auteurs

Min Li (M)

MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing University, Pukou District, Nanjing 210061, China.

Chao Quan (C)

MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing University, Pukou District, Nanjing 210061, China.

Shuai Chen (S)

MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing University, Pukou District, Nanjing 210061, China; Nanjing Biomedical Research Institute, Nanjing University, Nanjing 210061, China. Electronic address: chenshuai@nju.edu.cn.

Hong Yu Wang (HY)

MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing University, Pukou District, Nanjing 210061, China. Electronic address: wanghy@nicemice.cn.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines adaptatrices de la transduction du signal › Protéines 14-3-3 › The 14-3-3 protein is an essential component...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système locomoteur › Mouvement › Locomotion › Taxie › Chimiotaxie › The 14-3-3 protein is an essential component...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Ribonucléotides › Nucléotides adényliques › AMP cyclique › The 14-3-3 protein is an essential component...
questionsmedicales.fr › Eucaryotes › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium › The 14-3-3 protein is an essential component...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de protozoaire › The 14-3-3 protein is an essential component...