PGE

Aging / physiology Animals Bronchoalveolar Lavage Fluid / immunology Dinoprostone / metabolism Female Lung / immunology Macrophages, Alveolar / immunology Mice Mice, Inbred C57BL Mice, Knockout Receptors, Prostaglandin E, EP2 Subtype / genetics Smoking / adverse effects

Journal

Life science alliance
ISSN: 2575-1077
Titre abrégé: Life Sci Alliance
Pays: United States
ID NLM: 101728869

Informations de publication

Date de publication:
11 2020
Historique:
received: 29 05 2020
revised: 13 08 2020
accepted: 14 08 2020
entrez: 22 8 2020
pubmed: 21 8 2020
medline: 17 7 2021
Statut: epublish

Résumé

Alveolar macrophages (AMs) are resident immune cells of the lung that are critical for host defense. AMs are capable of proliferative renewal, yet their numbers are known to decrease with aging and increase with cigarette smoking. The mechanism by which AM proliferation is physiologically restrained, and whether dysregulation of this brake contributes to altered AM numbers in pathologic circumstances, however, remains unknown. Mice of advanced age exhibited diminished basal AM numbers and contained elevated PGE

Identifiants

DOI: 10.26508/lsa.202000800 PMID: 32820026 PMC: PMC7441521
pubmed: 32820026
pii: 3/11/e202000800
doi: 10.26508/lsa.202000800
pmc: PMC7441521
pii:
doi:

Substances chimiques

Ptger2 protein, mouse 0
Receptors, Prostaglandin E, EP2 Subtype 0
Dinoprostone K7Q1JQR04M

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NIAID NIH HHS
ID : R01 AI138347
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG024824
Pays : United States
Organisme : CSRD VA
ID : I01 CX000911
Pays : United States
Organisme : NHLBI NIH HHS
ID : R35 HL144979
Pays : United States
Organisme : CSRD VA
ID : I01 CX001553
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL007749
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000043
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL098961
Pays : United States
Organisme : NIA NIH HHS
ID : K07 AG050096
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL125555
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI007413
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG028082
Pays : United States

Informations de copyright

© 2020 Penke et al.

Références

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Auteurs

Loka R Penke (LR)

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.
ORCID: 0000-0002-2780-7950

Jennifer M Speth (JM)

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.

Christina Draijer (C)

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.

Zbigniew Zaslona (Z)

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.

Judy Chen (J)

Graduate Program in Immunology, University of Michigan Medical School, Ann Arbor, MI, USA.
Division of Cardiology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.
ORCID: 0000-0002-5469-6619

Peter Mancuso (P)

Graduate Program in Immunology, University of Michigan Medical School, Ann Arbor, MI, USA.
Department of Nutritional Sciences, University of Michigan School of Public Health, Ann Arbor, MI, USA.

Christine M Freeman (CM)

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.
Graduate Program in Immunology, University of Michigan Medical School, Ann Arbor, MI, USA.
Research Service, Veterans Affairs Ann Arbor Healthcare System, Ann Arbor, MI, USA.

Jeffrey L Curtis (JL)

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.
Graduate Program in Immunology, University of Michigan Medical School, Ann Arbor, MI, USA.
Medical Service, Veterans Affairs Ann Arbor Healthcare System, Ann Arbor, MI, USA.
ORCID: 0000-0001-5191-4847

Daniel R Goldstein (DR)

Graduate Program in Immunology, University of Michigan Medical School, Ann Arbor, MI, USA.
Division of Cardiology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.
Institute of Gerontology, University of Michigan, Ann Arbor, MI, USA.
ORCID: 0000-0001-6695-979X

Marc Peters-Golden (M)

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA petersm@umich.edu.
Graduate Program in Immunology, University of Michigan Medical School, Ann Arbor, MI, USA.
ORCID: 0000-0002-9768-0262

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › PGE
questionsmedicales.fr › Eucaryotes › Animaux › PGE
questionsmedicales.fr › Techniques d'investigation › Irrigation thérapeutique › Lavage bronchoalvéolaire › Liquide de lavage bronchoalvéolaire › PGE
questionsmedicales.fr › Facteurs biologiques › Médiateurs de l'inflammation › Autacoïdes › Éicosanoïdes › Prostaglandines › Prostaglandines E › Dinoprostone › PGE
questionsmedicales.fr › Appareil respiratoire › Poumon › PGE
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Macrophages › Macrophages alvéolaires › PGE
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › PGE
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › PGE
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › PGE
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs couplés aux protéines G › Récepteurs aux éicosanoïdes › Récepteur prostaglandine › Récepteur prostaglandine E › Sous-type EP2 des récepteurs des prostaglandines E › PGE
questionsmedicales.fr › Comportement et mécanismes comportementaux › Comportement › Fumer › PGE