CaMKIIδC Drives Early Adaptive Ca
Animals
Aorta
Arrhythmias, Cardiac
/ etiology
Calcium
/ metabolism
Calcium-Binding Proteins
/ metabolism
Calcium-Calmodulin-Dependent Protein Kinase Type 2
/ genetics
Cardiac Pacing, Artificial
Cardiomegaly
/ metabolism
Cell Nucleus
/ metabolism
Constriction
Cytosol
/ metabolism
Disease Progression
Gene Expression Profiling
Heart Failure
/ etiology
Histone Deacetylases
/ metabolism
Humans
Mice
Mice, Knockout
Mice, Transgenic
Myocytes, Cardiac
/ cytology
Sarcoplasmic Reticulum
/ metabolism
Sarcoplasmic Reticulum Calcium-Transporting ATPases
/ metabolism
Time Factors
Transcriptional Activation
CaMKII
calcium
heart failure
hypertrophy
mice
Journal
Circulation research
ISSN: 1524-4571
Titre abrégé: Circ Res
Pays: United States
ID NLM: 0047103
Informations de publication
Date de publication:
09 10 2020
09 10 2020
Historique:
pubmed:
22
8
2020
medline:
25
5
2021
entrez:
22
8
2020
Statut:
ppublish
Résumé
CaMKII (Ca To measure time- and location-dependent activation of CaMKIIδC signaling in adult ventricular cardiomyocytes, during transaortic constriction (TAC) and in CaMKIIδC transgenic mice. We used human tissue from nonfailing and HF hearts, 4 mouse lines: wild-type, KO (CaMKIIδ-knockout), CaMKIIδC transgenic in wild-type (TG), or KO background, and wild-type mice exposed to TAC. Confocal imaging and biochemistry revealed disproportional CaMKIIδC activation and accumulation in nuclear and perinuclear versus cytosolic regions at 5 days post-TAC. This CaMKIIδ activation caused a compensatory increase in sarcoplasmic reticulum Ca We conclude that in early TAC perinuclear CaMKIIδC activation promotes adaptive increases in myocyte Ca
Identifiants
pubmed: 32821022
doi: 10.1161/CIRCRESAHA.120.316947
pmc: PMC7547876
mid: NIHMS1623696
doi:
Substances chimiques
Calcium-Binding Proteins
0
phospholamban
0
Calcium-Calmodulin-Dependent Protein Kinase Type 2
EC 2.7.11.17
Hdac5 protein, mouse
EC 3.5.1.98
Histone Deacetylases
EC 3.5.1.98
Sarcoplasmic Reticulum Calcium-Transporting ATPases
EC 3.6.3.8
Atp2a2 protein, mouse
EC 7.2.2.10
Calcium
SY7Q814VUP
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1159-1178Subventions
Organisme : NHLBI NIH HHS
ID : K99 HL138160
Pays : United States
Organisme : NHLBI NIH HHS
ID : R00 HL138160
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL092097
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL141084
Pays : United States
Organisme : Austrian Science Fund FWF
ID : I 3301
Pays : Austria
Organisme : NHLBI NIH HHS
ID : R37 HL028143
Pays : United States
Organisme : NHLBI NIH HHS
ID : R37 HL030077
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL145459
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL142282
Pays : United States
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