[Macular edema: Understand mechanisms to develop treatments].
Les œdèmes maculaires - Mieux comprendre leurs mécanismes pour mieux les traiter.
Journal
Medecine sciences : M/S
ISSN: 1958-5381
Titre abrégé: Med Sci (Paris)
Pays: France
ID NLM: 8710980
Informations de publication
Date de publication:
Historique:
entrez:
22
8
2020
pubmed:
22
8
2020
medline:
10
10
2020
Statut:
ppublish
Résumé
Macular edema is an increase in volume of the central area of the retina, responsible for visual acuity. Visual symptoms handicap the lives of millions of patients with macular edema secondary to chronic and sometimes acute retinal disease. Proteins that neutralize the vascular endothelial growth factor (VEGF) pathway or glucocorticoids, at the cost of repeated intraocular injections over years, limit visual symptoms. A better understanding of why and how edema forms and how therapeutic molecules exert an anti-edematous effect will help prevent this disabling and blinding retinal complication from occurring. Les œdèmes maculaires - Mieux comprendre leurs mécanismes pour mieux les traiter. L’œdème maculaire est une augmentation de volume de la macula, zone centrale de la rétine, responsable de l’acuité visuelle. Des symptômes visuels handicapent la vie de millions de patients atteints d’œdème maculaire secondaire à une maladie chronique et parfois aiguë de la rétine. Les protéines qui neutralisent la voie du facteur de croissance de l’endothélium vasculaire (VEGF) ou les glucocorticoïdes, au prix d’injections intraoculaires répétées pendant des années, limitent les symptômes visuels. Mieux comprendre pourquoi et comment l’œdème se forme et comment les molécules thérapeutiques exercent un effet anti-œdémateux permettra de mieux prévenir la survenue de cette complication rétinienne handicapante et cécitante.
Autres résumés
Type: Publisher
(fre)
Les œdèmes maculaires - Mieux comprendre leurs mécanismes pour mieux les traiter.
Identifiants
pubmed: 32821052
doi: 10.1051/medsci/2020130
pii: msc200104
doi:
Substances chimiques
Angiogenesis Inhibitors
0
Antibodies, Monoclonal, Humanized
0
Glucocorticoids
0
Vascular Endothelial Growth Factor A
0
Types de publication
Journal Article
Review
Langues
fre
Sous-ensembles de citation
IM
Pagination
753-762Informations de copyright
© 2020 médecine/sciences – Inserm.
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