Linking LOXL2 to Cardiac Interstitial Fibrosis.
DNA methylation
Lysyl Oxidase-Like 2 (LOXL2)
cardiovascular disease (CVD)
epigenetics
fibrosis
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
18 Aug 2020
18 Aug 2020
Historique:
received:
08
07
2020
revised:
23
07
2020
accepted:
29
07
2020
entrez:
23
8
2020
pubmed:
23
8
2020
medline:
17
2
2021
Statut:
epublish
Résumé
Cardiovascular diseases (CVDs) are the leading causes of death worldwide. CVD pathophysiology is often characterized by increased stiffening of the heart muscle due to fibrosis, thus resulting in diminished cardiac function. Fibrosis can be caused by increased oxidative stress and inflammation, which is strongly linked to lifestyle and environmental factors such as diet, smoking, hyperglycemia, and hypertension. These factors can affect gene expression through epigenetic modifications. Lysyl oxidase like 2 (LOXL2) is responsible for collagen and elastin cross-linking in the heart, and its dysregulation has been pathologically associated with increased fibrosis. Additionally, studies have shown that, LOXL2 expression can be regulated by DNA methylation and histone modification. However, there is a paucity of data on LOXL2 regulation and its role in CVD. As such, this review aims to gain insight into the mechanisms by which LOXL2 is regulated in physiological conditions, as well as determine the downstream effectors responsible for CVD development.
Identifiants
pubmed: 32824630
pii: ijms21165913
doi: 10.3390/ijms21165913
pmc: PMC7460598
pii:
doi:
Substances chimiques
Amino Acid Oxidoreductases
EC 1.4.-
LOXL2 protein, human
EC 1.4.3.-
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Research Foundation
ID : 104912
Organisme : South African Medical Research Council
ID : Baseline Funding
Organisme : South African Medical Research Council
ID : Division of Research Capacity Development Post Doctoral program
Organisme : National Research Foundation
ID : 12098
Organisme : Thuthuka Programme Grant
ID : 107261
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