Cardiovascular effects of increasing dosages of norepinephrine in healthy isoflurane-anesthetized New Zealand White rabbits.
blood pressure
hypotension
isoflurane
norepinephrine
rabbits
sympathomimetics
Journal
Veterinary anaesthesia and analgesia
ISSN: 1467-2995
Titre abrégé: Vet Anaesth Analg
Pays: United States
ID NLM: 100956422
Informations de publication
Date de publication:
Nov 2020
Nov 2020
Historique:
received:
29
01
2020
revised:
29
06
2020
accepted:
01
07
2020
pubmed:
23
8
2020
medline:
13
7
2021
entrez:
23
8
2020
Statut:
ppublish
Résumé
To characterize the cardiovascular effects of increasing dosages of norepinephrine (NE) in healthy isoflurane-anesthetized rabbits. Prospective experimental study. A total of nine female ovariohysterectomized New Zealand White rabbits weighing 3.4 ± 0.2 kg (mean ± standard deviation). Rabbits were premedicated intramuscularly with buprenorphine (0.05 mg kg Significant increases in SAP (28% and 90%), MAP (27% and 90%) and DAP (33% and 97%) were measured with medium and high dose treatments, respectively (p < 0.001), with no changes in CO. HR decreased and stroke volume increased significantly with high dose treatment (by 17% and 15%, respectively; p < 0.05). No arrhythmias were noticed with NE treatments. The infusion of NE at 0.5-1.0 μg kg
Identifiants
pubmed: 32826161
pii: S1467-2987(20)30128-8
doi: 10.1016/j.vaa.2020.07.001
pii:
doi:
Substances chimiques
Sympathomimetics
0
Carbon Monoxide
7U1EE4V452
Isoflurane
CYS9AKD70P
Norepinephrine
X4W3ENH1CV
Types de publication
Clinical Trial, Veterinary
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
781-788Informations de copyright
Crown Copyright © 2020. Published by Elsevier Ltd. All rights reserved.