Printable microscale interfaces for long-term peripheral nerve mapping and precision control.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
21 08 2020
21 08 2020
Historique:
received:
13
09
2019
accepted:
29
07
2020
entrez:
23
8
2020
pubmed:
23
8
2020
medline:
15
9
2020
Statut:
epublish
Résumé
The nascent field of bioelectronic medicine seeks to decode and modulate peripheral nervous system signals to obtain therapeutic control of targeted end organs and effectors. Current approaches rely heavily on electrode-based devices, but size scalability, material and microfabrication challenges, limited surgical accessibility, and the biomechanically dynamic implantation environment are significant impediments to developing and deploying peripheral interfacing technologies. Here, we present a microscale implantable device - the nanoclip - for chronic interfacing with fine peripheral nerves in small animal models that begins to meet these constraints. We demonstrate the capability to make stable, high signal-to-noise ratio recordings of behaviorally-linked nerve activity over multi-week timescales. In addition, we show that multi-channel, current-steering-based stimulation within the confines of the small device can achieve multi-dimensional control of a small nerve. These results highlight the potential of new microscale design and fabrication techniques for realizing viable devices for long-term peripheral interfacing.
Identifiants
pubmed: 32826892
doi: 10.1038/s41467-020-18032-4
pii: 10.1038/s41467-020-18032-4
pmc: PMC7442820
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4191Subventions
Organisme : NINDS NIH HHS
ID : R01 NS089679
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS104925
Pays : United States
Organisme : NEI NIH HHS
ID : R21 EY027588
Pays : United States
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