Optimised collection of non-uniformly sampled 2D-HSQC NMR spectra for use in metabolic flux analysis.
MFA
NMR
NUS
isotopomers
metabolism
tracer
Journal
Magnetic resonance in chemistry : MRC
ISSN: 1097-458X
Titre abrégé: Magn Reson Chem
Pays: England
ID NLM: 9882600
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
received:
03
04
2020
revised:
06
08
2020
accepted:
18
08
2020
pubmed:
25
8
2020
medline:
20
7
2021
entrez:
25
8
2020
Statut:
ppublish
Résumé
Nuclear magnetic resonance (NMR) spectroscopy is integral to metabolic studies; yet, it can suffer from the long acquisition times required to collect data of sufficient signal strength and resolution. The use of non-uniform sampling (NUS) allows faster collection of NMR spectra without loss of spectral integrity. When planning experimental methodologies to perform metabolic flux analysis (MFA) of cell metabolism, a variety of options are available for the acquisition of NUS NMR data. Before beginning data collection, decisions have to be made regarding selection of pulse sequence, number of transients and NUS specific parameters such as the sampling level and sampling schedule. Poor choices will impact data quality, which may have a negative effect on the subsequent analysis and biological interpretation. Herein, we describe factors that should be considered when setting up non-uniformly sampled 2D-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
287-299Subventions
Organisme : Institutional Strategic Support Award given to the
Organisme : UHB Charitable Funds
ID : 17-3-846
Organisme : Wellcome Trust
ID : 208400/Z/17/Z
Pays : United Kingdom
Informations de copyright
© 2020 The Authors. Magnetic Resonance in Chemistry published by John Wiley & Sons Ltd.
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