Gender and birth weight as risk factors for anastomotic stricture after esophageal atresia repair: a systematic review and meta-analysis.
Anastomotic stricture
Birth weight
Esophageal atresia repair
Gender
Meta-analysis
Risk factors
Journal
BMC pediatrics
ISSN: 1471-2431
Titre abrégé: BMC Pediatr
Pays: England
ID NLM: 100967804
Informations de publication
Date de publication:
24 08 2020
24 08 2020
Historique:
received:
28
03
2020
accepted:
13
08
2020
entrez:
25
8
2020
pubmed:
25
8
2020
medline:
15
5
2021
Statut:
epublish
Résumé
Anastomotic stricture (AS) is the most frequently occurring complication that occurs after esophageal atresia (EA) repair. Nevertheless, the pathogenesis remains primarily unknown and there is inadequate knowledge regarding the risk factors for AS. Therefore, a systematic review of the literature and a meta-analysis was performed to investigate whether gender and birth weight were risk factors for the development of AS following EA repair. The main outcome measure was the occurrence of AS. Forest plots with odds ratios (OR) and 95% confidence intervals (CI) were generated for the outcomes. Quality assessment was performed using the Newcastle-Ottawa scale. Six studies with a total of 495 patients were included; 59% males, and 37 and 63% of the patients weighed < 2500 g and ≥ 2500 g, respectively. Male gender (OR, 0.96; 95% CI, 0.66-1.40; p = 0.82) and birth weight < 2500 g (OR, 0.74; 95% CI, 0.47-1.15; p = 0.18) did not increase the risk of AS. The majority of the included studies were retrospective cohort studies and the overall risk of bias was considered to be low to moderate. Neither gender nor birth weight appear to have an impact on the risk of AS development following EA repair.
Sections du résumé
BACKGROUND
Anastomotic stricture (AS) is the most frequently occurring complication that occurs after esophageal atresia (EA) repair. Nevertheless, the pathogenesis remains primarily unknown and there is inadequate knowledge regarding the risk factors for AS. Therefore, a systematic review of the literature and a meta-analysis was performed to investigate whether gender and birth weight were risk factors for the development of AS following EA repair.
METHODS
The main outcome measure was the occurrence of AS. Forest plots with odds ratios (OR) and 95% confidence intervals (CI) were generated for the outcomes. Quality assessment was performed using the Newcastle-Ottawa scale.
RESULTS
Six studies with a total of 495 patients were included; 59% males, and 37 and 63% of the patients weighed < 2500 g and ≥ 2500 g, respectively. Male gender (OR, 0.96; 95% CI, 0.66-1.40; p = 0.82) and birth weight < 2500 g (OR, 0.74; 95% CI, 0.47-1.15; p = 0.18) did not increase the risk of AS. The majority of the included studies were retrospective cohort studies and the overall risk of bias was considered to be low to moderate.
CONCLUSION
Neither gender nor birth weight appear to have an impact on the risk of AS development following EA repair.
Identifiants
pubmed: 32831054
doi: 10.1186/s12887-020-02295-3
pii: 10.1186/s12887-020-02295-3
pmc: PMC7444057
doi:
Types de publication
Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
400Références
PLoS One. 2014 Aug 25;9(8):e106149
pubmed: 25153838
Paediatr Respir Rev. 2016 Jun;19:10-5
pubmed: 27217220
Nephron Clin Pract. 2010;116(4):c317-21
pubmed: 20664286
J Am Heart Assoc. 2014 Feb 04;3(1):e000608
pubmed: 24496232
Early Hum Dev. 2014 Dec;90(12):947-50
pubmed: 25448787
Arch Pediatr. 2001 Mar;8(3):268-74
pubmed: 11270250
World J Gastroenterol. 2012 Jul 28;18(28):3662-72
pubmed: 22851858
Eur J Pediatr Surg. 2013 Jun;23(3):204-13
pubmed: 23720206
Arch Dis Child. 2012 Mar;97(3):227-32
pubmed: 22247246
J Pediatr Surg. 2013 Aug;48(8):1650-6
pubmed: 23932602
Surg Res Pract. 2017;2017:8345798
pubmed: 29201998
Pediatr Surg Int. 2018 May;34(5):491-497
pubmed: 29536176
Pediatr Surg Int. 2016 Sep;32(9):869-73
pubmed: 27461430
PLoS Med. 2009 Jul 21;6(7):e1000097
pubmed: 19621072
J Laparoendosc Adv Surg Tech A. 2016 May;26(5):393-8
pubmed: 26895295
Eur J Pediatr Surg. 2017 Feb;27(1):50-55
pubmed: 27769086
Eur J Pediatr Surg. 2017 Apr;27(2):192-195
pubmed: 27214095
Orphanet J Rare Dis. 2007 May 11;2:24
pubmed: 17498283