Modulation of Lymphocyte Potassium Channel K


Journal

ACS pharmacology & translational science
ISSN: 2575-9108
Titre abrégé: ACS Pharmacol Transl Sci
Pays: United States
ID NLM: 101721411

Informations de publication

Date de publication:
14 Aug 2020
Historique:
received: 10 04 2020
entrez: 25 8 2020
pubmed: 25 8 2020
medline: 25 8 2020
Statut: epublish

Résumé

We describe a cysteine-rich, membrane-penetrating, joint-targeting, and remarkably stable peptide, EgK5, that modulates voltage-gated K

Identifiants

pubmed: 32832873
doi: 10.1021/acsptsci.0c00035
pmc: PMC7432667
doi:

Types de publication

Journal Article

Langues

eng

Pagination

720-736

Subventions

Organisme : NHGRI NIH HHS
ID : U54 HG006348
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL007676
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS100294
Pays : United States
Organisme : NHGRI NIH HHS
ID : U54 HG006364
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA125123
Pays : United States
Organisme : NHGRI NIH HHS
ID : UM1 HG006348
Pays : United States

Informations de copyright

Copyright © 2020 American Chemical Society.

Déclaration de conflit d'intérêts

The authors declare no competing financial interest.

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Auteurs

Seow Theng Ong (ST)

Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Experimental Medicine Building, 59 Nanyang Drive, Singapore 636921.

Saumya Bajaj (S)

Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Experimental Medicine Building, 59 Nanyang Drive, Singapore 636921.

Mark R Tanner (MR)

Department of Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, United States.

Shih Chieh Chang (SC)

Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Experimental Medicine Building, 59 Nanyang Drive, Singapore 636921.

Bankala Krishnarjuna (B)

Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.

Xuan Rui Ng (XR)

Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Experimental Medicine Building, 59 Nanyang Drive, Singapore 636921.

Rodrigo A V Morales (RAV)

Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.

Ming Wei Chen (MW)

Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Experimental Medicine Building, 59 Nanyang Drive, Singapore 636921.

Dahai Luo (D)

Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Experimental Medicine Building, 59 Nanyang Drive, Singapore 636921.

Dharmeshkumar Patel (D)

School of Physics, University of Sydney, Sydney, New South Wales 2006, Australia.

Sabina Yasmin (S)

School of Physics, University of Sydney, Sydney, New South Wales 2006, Australia.

Jeremy Jun Heng Ng (JJH)

Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Experimental Medicine Building, 59 Nanyang Drive, Singapore 636921.

Zhong Zhuang (Z)

Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Experimental Medicine Building, 59 Nanyang Drive, Singapore 636921.

Hai M Nguyen (HM)

Department of Pharmacology, University of California, Davis, California 95616, United States.

Abbas El Sahili (A)

School of Biological Sciences, Nanyang Institute of Structural Biology, Experimental Medicine building, Singapore 636921.

Julien Lescar (J)

School of Biological Sciences, Nanyang Institute of Structural Biology, Experimental Medicine building, Singapore 636921.

Rahul Patil (R)

Centre for Drug Candidate Optimisation, Monash University, Parkville, Victoria 3052, Australia.

Susan A Charman (SA)

Centre for Drug Candidate Optimisation, Monash University, Parkville, Victoria 3052, Australia.

Edward G Robins (EG)

Singapore Bioimaging Consortium, Agency for Science, Technology and Research (A Star), Singapore 138667.
Singapore Bioimaging Consortium, NUS Clinical Imaging Research Centre (CIRC), Centre for Life Sciences, Singapore 117599.

Julian L Goggi (JL)

Singapore Bioimaging Consortium, Agency for Science, Technology and Research (A Star), Singapore 138667.

Peng Wen Tan (PW)

Singapore Bioimaging Consortium, Agency for Science, Technology and Research (A Star), Singapore 138667.

Pragalath Sadasivam (P)

Singapore Bioimaging Consortium, Agency for Science, Technology and Research (A Star), Singapore 138667.

Boominathan Ramasamy (B)

Singapore Bioimaging Consortium, Agency for Science, Technology and Research (A Star), Singapore 138667.

Siddana V Hartimath (SV)

Singapore Bioimaging Consortium, Agency for Science, Technology and Research (A Star), Singapore 138667.

Vikas Dhawan (V)

Peptides International, Inc., Louisville, Kentucky 40269, United States.
AmbioPharm Inc., North Augusta, South Carolina 29842, United States.

Janna Bednenko (J)

TetraGenetics Inc, Arlington, Massachusetts 02474, United States.

Paul Colussi (P)

TetraGenetics Inc, Arlington, Massachusetts 02474, United States.

Heike Wulff (H)

Department of Pharmacology, University of California, Davis, California 95616, United States.

Michael W Pennington (MW)

Peptides International, Inc., Louisville, Kentucky 40269, United States.
AmbioPharm Inc., North Augusta, South Carolina 29842, United States.

Serdar Kuyucak (S)

School of Physics, University of Sydney, Sydney, New South Wales 2006, Australia.

Raymond S Norton (RS)

Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.
ARC Centre for Fragment-Based Design, Monash University, Parkville, Victoria 3052, Australia.

Christine Beeton (C)

Department of Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, United States.

K George Chandy (KG)

Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Experimental Medicine Building, 59 Nanyang Drive, Singapore 636921.

Classifications MeSH